ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Microtubule reconfiguration during axonal retraction induced by nitric oxide.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Article
- Cofilin dysregulation alters actin turnover in frataxin-deficient neurons.Scientific reports · 2020Article
- FOXO Regulates Neuromuscular Junction Homeostasis DuringFrontiers in aging neuroscience · 2020Article
- The Roles of Microtubules and Membrane Tension in Axonal Beading, Retraction, and Atrophy.Biophysical journal · 2019Article
- Tension- and Adhesion-Regulated Retraction of Injured Axons.Biophysical journal · 2019Article
- Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cytoskeletal Mechanisms of Axonal Contractility.Biophysical journal · 2018Article
- The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.Cell reports · 2017Article
- Article
- Different modes of growth cone collapse in NG 108-15 cells.European biophysics journal : EBJ · 2013Article
- Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective.Scientific reports · 2013Article
- Active endocytosis and microtubule remodeling restore compressed pyramidal neuron morphology in rat cerebral cortex.Cellular and molecular neurobiology · 2012Article
- Selective vulnerability of synaptic signaling and metabolism to nitrosative stress.Antioxidants & redox signaling · 2012Review
- Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.The Journal of biological chemistry · 2011Article
- NMDA receptor activation suppresses microtubule growth and spine entry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway.Environmental health perspectives · 2010Article
- Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.The Journal of cell biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal retraction is induced by different types of physiological cues and is responsible for the elimination of mistargeted axons. There is broad agreement that alterations in the cytoskeleton underlie axonal retraction. The prevailing view is that axonal retraction involves a wholesale depolymerization of microtubules and microfilaments. However, axons retracting physiologically display a very different morphology than axons induced to retract by experimental depolymerization of microtubules. Experimental depolymerization of microfilaments actually prevents retraction rather than causing it. We have proposed an alternative hypothesis, namely that axonal retraction involves a backward retreat of cytoskeletal elements rather than their wholesale depolymerization. In the present study, we sought to test this hypothesis with regard to microtubules. When a donor of nitric oxide was applied to cultured chick sensory neurons, the majority of axons retracted dramatically within 30-60 min. Retracting axons were characterized by an enlarged distal region, a thin trailing remnant, and sinusoidal bends along the shaft. Quantitative immunofluorescence analyses showed no detectable loss of microtubule mass during retraction, even with regard to the most labile microtubules. Instead, microtubules were reconfigured into coiling and sinusoidal bundles to accommodate the shortening of the axon. Stabilization of microtubules by taxol did not prevent the retraction, even at concentrations of the drug that actually caused microtubule levels to increase. The retractions induced by nitric oxide were remarkably similar to those observed when motor proteins are manipulated, suggesting that these retractions may result from alterations in the activities of the motors that configure microtubules.
Indexed as
Identifiers
12122060PMC6757941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.