ArticleAntimicrobial agents and chemotherapy2002
Tn5406, a new staphylococcal transposon conferring resistance to streptogramin a and related compounds including dalfopristin.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GEMicrobiology spectrum · 2023Article
- Vancomycin Resistance inMicroorganisms · 2022Review
- Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022Review
- TnCentral: a Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis.mBio · 2021Article
- TnAntimicrobial agents and chemotherapy · 2019Article
- Staphylococcal Plasmids, Transposable and Integrative Elements.Microbiology spectrum · 2018Review
- Small Antimicrobial Resistance Plasmids in Livestock-Associated Methicillin-ResistantFrontiers in microbiology · 2018Review
- Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.Cold Spring Harbor perspectives in medicine · 2016Review
- Article
- A novel fexA variant from a canine Staphylococcus pseudintermedius isolate that does not confer florfenicol resistance.Antimicrobial agents and chemotherapy · 2013Article
- Resistance Genes Underlying the LSAntimicrobial agents and chemotherapy · 2013Article
- Tn6188 - a novel transposon in Listeria monocytogenes responsible for tolerance to benzalkonium chloride.PloS one · 2013Article
- whole-genome sequence of livestock-associated st398 methicillin-resistant staphylococcus aureus Isolated from Humans in Canada.Journal of bacteriology · 2012Article
- Article
- New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene.Antimicrobial agents and chemotherapy · 2011Article
- Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium.Antimicrobial agents and chemotherapy · 2010Article
- Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain.Antimicrobial agents and chemotherapy · 2010Article
- Emergence of pristinamycin resistance in India.Indian journal of pharmacology · 2009Article
- DNA microarray for detection of macrolide resistance genes.Antimicrobial agents and chemotherapy · 2006Article
- Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria.Journal of clinical microbiology · 2005Article
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3 authors.
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Abstract
We characterized a new transposon, Tn5406 (5,467 bp), in a clinical isolate of Staphylococcus aureus (BM3327). It carries a variant of vgaA, which encodes a putative ABC protein conferring resistance to streptogramin A but not to mixtures of streptogramins A and B. It also carries three putative genes, the products of which exhibit significant similarities (61 to 73% amino acid identity) to the three transposases of the staphylococcal transposon Tn554. Like Tn554, Tn5406 failed to generate target repeats. In BM3327, the single copy of Tn5406 was inserted into the chromosomal att554 site, which is the preferential insertion site of Tn554. In three other independent S. aureus clinical isolates, Tn5406 was either present as a single plasmid copy (BM3318), as two chromosomal copies (BM3252), or both in the chromosome and on a plasmid (BM3385). The Tn5406-carrying plasmids also contain two other genes, vgaB and vatB. The insertion sites of Tn5406 in BM3252 were studied: one copy was in att554, and one copy was in the additional SCCmec element. Amplification experiments revealed circular forms of Tn5406, indicating that this transposon might be active. To our knowledge, a transposon conferring resistance to streptogramin A and related compounds has not been previously described.
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