ArticleAmerican journal of human genetics2002
A major susceptibility gene for asthma maps to chromosome 14q24.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.European journal of human genetics : EJHG · 2010Pooled it
- A genome-wide association study on African-ancestry populations for asthma.The Journal of allergy and clinical immunology · 2010Pooled it
- Meta-analysis of genome-wide linkage studies of asthma and related traits.Respiratory research · 2008Pooled it
- Pooled it
- Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.Scientific reports · 2025Article
- Arginine metabolic control of airway inflammation.JCI insight · 2020Article
- Article
- Pharmacogenomics of Prostaglandin and Leukotriene Receptors.Frontiers in pharmacology · 2016Review
- Genetics of allergic diseases.Immunology and allergy clinics of North America · 2015Review
- An understanding of the genetic basis of asthma.The Indian journal of medical research · 2011Review
- Regulating the Regulators: microRNA and Asthma.The World Allergy Organization journal · 2011Article
- Genomewide association studies in allergy and the influence of ethnicity.Current opinion in allergy and clinical immunology · 2010Review
- A sequence variant on 17q21 is associated with age at onset and severity of asthma.European journal of human genetics : EJHG · 2010Article
- Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.The European respiratory journal · 2010Article
- Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.Toxicology and applied pharmacology · 2009Article
- IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2008Article
- Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases.Translational research : the journal of laboratory and clinical medicine · 2008Review
- Asthma from a pharmacogenomic point of view.British journal of pharmacology · 2008Review
- Prolonged signal-averaged P-wave duration as an intermediate phenotype for familial atrial fibrillation.Journal of the American College of Cardiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Numerous loci and candidate genes have been reported to show linkage and association to asthma and atopy. Although some studies reporting these observations are compelling, no gene has been mapped that confers a sufficiently high risk of asthma to meet the stringent criteria for genomewide significance. Using 175 extended Icelandic families that included 596 patients with asthma, we performed a genomewide scan with 976 microsatellite markers. The families were identified by cross-matching a list of patients with asthma from the Department of Allergy/Pulmonary Medicine of the National University Hospital of Iceland with a genealogy database of the entire Icelandic nation. We detected linkage of asthma to chromosome 14q24, with an allele-sharing LOD score of 2.66. After we increased the marker density within the locus to an average of one microsatellite every 0.2 cM, the LOD score rose to 4.00. We designate this locus "asthma locus one" (AS1). Taken together, these results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.