ArticleProceedings of the National Academy of Sciences of the United States of America2002
Punctuated evolution of mitochondrial gene content: high and variable rates of mitochondrial gene loss and transfer to the nucleus during angiosperm evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 251 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
251 citing papers in PubMed, 1 synthesis or guideline pooled it, 492 citations in OpenAlex.
- A Systematic Review and Developmental Perspective on Origin of CMS Genes in Crops.International journal of molecular sciences · 2024Pooled it
- Exploring the Mitochondrial Genomes ofEcology and evolution · 2026Article
- Assembly and comparative analysis of the complete mitochondrial genome of Viola philippica (Malpighiales, Violaceae).Planta · 2026Article
- Characterization of mitochondrial genomes from three medicinal species of rutaceae and comparative analysis within the family: insights into evolution.BMC genomics · 2026Article
- Comparative analysis of the complete multi-chromosomal mitogenome of Anoectochilus emeiensis (Orchidaceae).BMC plant biology · 2026Article
- The Effects of Rapid Mitochondrial Gene Loss on Organellar Proteomes.Genome biology and evolution · 2026Article
- Silene, a versatile model system: from sex and genome evolution to ecology and speciation.The New phytologist · 2026Review
- Assembly and comparative analysis of the initial complete mitochondrial genome of Verbascum thapsus (Scrophulariaceae): a medicinally and ecologically significant species.BMC plant biology · 2026Article
- Complete mitochondrial genomes of the two high-valued bromeliads: comparative genomics and evolutionary insights.BMC genomics · 2026Article
- Comparative analysis of multi-chromosomal mitochondrial genome of Bletilla striata: homologous recombination mediated by repetitive sequences.BMC plant biology · 2026Article
- Comprehensive Analysis of the Complete Mitochondrial Genomes ofInternational journal of molecular sciences · 2026Article
- Plastid genomes and phylogenomic relationships in Cheilosoideae, a poorly known early-diverging subfamily of Euphorbiaceae.BMC plant biology · 2026Article
- The Mitochondrial Genome ofGenes · 2026Article
- Multipartite mitochondrial genome evolution in Halophila seagrasses: repeat-driven structural plasticity and selection signatures of marine adaptation.BMC plant biology · 2026Article
- The complete mitochondrial genome of Prinsepia uniflora (Rosaceae): De novo assembly, characterization, and phylogenetic analysis.BMC genomics · 2026Article
- De novo assembly of the first mitochondrial genome in Benincasa reveals structural dynamics and evolutionary insights in Cucurbitaceae.BMC plant biology · 2026Article
- Polyploidy drives structural and functional evolution in Camellia mitochondrial genomes.BMC genomics · 2026Article
- Assembly and comparative analysis of the complete mitochondrial genome of Tetrastigma Hemsleyanum Diels & Gilg: an invaluable traditional Chinese medicine.BMC plant biology · 2026Article
- Assembly and comparative analysis of the complete mitochondrial genome ofFrontiers in plant science · 2026Article
- Mitochondrial genome evolution of the hemiparasitic plantFrontiers in plant science · 2026Article
191 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To study the tempo and pattern of mitochondrial gene loss in plants, DNAs from 280 genera of flowering plants were surveyed for the presence or absence of 40 mitochondrial protein genes by Southern blot hybridization. All 14 ribosomal protein genes and both sdh genes have been lost from the mitochondrial genome many times (6 to 42) during angiosperm evolution, whereas only two losses were detected among the other 24 genes. The gene losses have a very patchy phylogenetic distribution, with periods of stasis followed by bursts of loss in certain lineages. Most of the oldest groups of angiosperms are still mired in a prolonged stasis in mitochondrial gene content, containing nearly the same set of genes as their algal ancestors more than a billion years ago. In sharp contrast, other plants have rapidly lost many or all of their 16 mitochondrial ribosomal protein and sdh genes, thereby converging on a reduced gene content more like that of an animal or fungus than a typical plant. In these and many lineages with more modest numbers of losses, the rate of ribosomal protein and sdh gene loss exceeds, sometimes greatly, the rate of mitochondrial synonymous substitutions. Most of these mitochondrial gene losses are probably the consequence of gene transfer to the nucleus; thus, rates of functional gene transfer also may vary dramatically in angiosperms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.