ArticleThe Journal of cell biology2002
Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- Computational Model of Complex Calcium Dynamics: Store Operated CaCell biochemistry and biophysics · 2025Article
- The role of CaCell calcium · 2023Review
- Modelling mechanism of calcium oscillations in pancreatic acinar cells.Journal of bioenergetics and biomembranes · 2014Article
- Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.Journal of biosciences · 2014Article
- A mixture of anatase and rutile TiO₂ nanoparticles induces histamine secretion in mast cells.Particle and fibre toxicology · 2012Article
- Mucin secretion induced by titanium dioxide nanoparticles.PloS one · 2011Article
- Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells.Pflugers Archiv : European journal of physiology · 2010Article
- A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.The Journal of physiology · 2005Article
- Twenty years of calcium imaging: cell physiology to dye for.Molecular interventions · 2005Review
- Calcium oscillations in a triplet of pancreatic acinar cells.Biophysical journal · 2005Article
- Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors.The Journal of cell biology · 2003Article
- A model of calcium waves in pancreatic and parotid acinar cells.Biophysical journal · 2003Article
- Ca2+ signalling and membrane current activated by cADPr in starfish oocytes.Pflugers Archiv : European journal of physiology · 2003Article
- Selective activation by photodynamic action of cholecystokinin receptor in the freshly isolated rat pancreatic acini.British journal of pharmacology · 2003Article
- Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells.The Biochemical journal · 2003Article
- Desert Island Papers.Brain and neuroscience advancesArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals in many cell types. However, it is inherently difficult to distinguish experimentally between the contributions of messenger-induced Ca2+ release and CICR. We have directly tested the CICR sensitivity of different regions of intact pancreatic acinar cells using local uncaging of caged Ca2+. In the apical region, local uncaging of Ca2+ was able to trigger a CICR wave, which propagated toward the base. CICR could not be triggered in the basal region, despite the known presence of ryanodine receptors. The triggering of CICR from the apical region was inhibited by a pharmacological block of ryanodine or inositol trisphosphate receptors, indicating that global signals require coordinated Ca2+ release. Subthreshold agonist stimulation increased the probability of triggering CICR by apical uncaging, and uncaging-induced CICR could activate long-lasting Ca2+ oscillations. However, with subthreshold stimulation, CICR could still not be initiated in the basal region. CICR is the major process responsible for global Ca2+ transients, and intracellular variations in sensitivity to CICR predetermine the activation pattern of Ca2+ waves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.