ArticleThe Journal of experimental medicine2002
On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 133 citations in OpenAlex.
- Article
- Article
- Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3Cellular immunology · 2020Review
- Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.PLoS genetics · 2020Article
- Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.Journal of autoimmunity · 2018Article
- Dendritic Cells As Inducers of Peripheral Tolerance.Trends in immunology · 2017Review
- Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation.Frontiers in immunology · 2017Review
- Article
- Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor-Mediated T Cell Tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis.Frontiers in immunology · 2016Review
- Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage.Journal of immunology research · 2015Review
- Tolerogenic dendritic cells and their applications in transplantation.Cellular & molecular immunology · 2015Review
- Sterile inflammation after permanent distal MCA occlusion in hypertensive rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses.Journal of neuroimmunology · 2014Article
- Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.PloS one · 2014Article
- Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases.Critical reviews in immunology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Recently, it has become clear that dendritic cells (DCs) are essential for the priming of T cell responses. However, their role in the maintenance of peripheral T cell tolerance remains largely undefined. Herein, an antigen-presenting cell (APC) transfer system was devised and applied to experimental allergic encephalomyelitis (EAE), to evaluate the contribution that DCs play in peripheral T cell tolerance. The CD8alpha(-)CD4(+) subset, a minor population among splenic DCs, was found to mediate both tolerance and bystander suppression against diverse T cell specificities. Aggregated (agg) Ig-myelin oligodendrocyte glycoprotein (MOG), an Ig chimera carrying the MOG 35-55 peptide, binds and cross-links FcgammaR on APC leading to efficient peptide presentation and interleukin (IL)-10 production. Furthermore, administration of agg Ig-MOG into diseased mice induces relief from clinical EAE involving multiple epitopes. Such recovery could not occur in FcgammaR-deficient mice where both uptake of Ig-MOG and IL-10 production are compromised. However, reconstitution of these mice with DC populations incorporating the CD8alpha(-)CD4(+) subset restored Ig-MOG-mediated reversal of EAE. Transfer of CD8alpha(+) or even CD8alpha(-)CD4(-) DCs had no effect on the disease. These findings strongly implicate DCs in peripheral tolerance and emphasize their functional potency, as a small population of DCs was able to support effective suppression of autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.