ArticleThe Journal of experimental medicine2002
Implications of phase variation of a gene (pgtA) encoding a pilin galactosyl transferase in gonococcal pathogenesis.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Molecular characterisation ofBMJ open · 2022Article
- Sculpting the BacterialmBio · 2022Article
- Case Report: Severe Disseminated Gonococcal Infection with Polyarticular Gout: Two Cases in Older Travelers.The American journal of tropical medicine and hygiene · 2019Article
- Subversion of the Immune Response by Human Pathogenic Mycoplasmas.Frontiers in microbiology · 2019Review
- Glycointeractions in bacterial pathogenesis.Nature reviews. Microbiology · 2018Review
- Emerging facets of prokaryotic glycosylation.FEMS microbiology reviews · 2017Review
- In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.BMC genomics · 2016Article
- Phase variable DNA repeats inMicrobial genomics · 2016Article
- Mycoplasma agalactiae Secretion of β-(1→6)-Glucan, a Rare Polysaccharide in Prokaryotes, Is Governed by High-Frequency Phase Variation.Applied and environmental microbiology · 2016Article
- The sweet tooth of bacteria: common themes in bacterial glycoconjugates.Microbiology and molecular biology reviews : MMBR · 2014Review
- Article
- Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans.Frontiers in endocrinology · 2014Article
- De novo synthesis of D- and L-fucosamine containing disaccharides.Beilstein journal of organic chemistry · 2013Article
- Hypomorphic glycosyltransferase alleles and recoding at contingency loci influence glycan microheterogeneity in the protein glycosylation system of Neisseria species.Journal of bacteriology · 2012Article
- Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells.Cellular microbiology · 2011Article
- Protein glycosylation in bacteria: sweeter than ever.Nature reviews. Microbiology · 2010Review
- Modification of the Campylobacter jejuni flagellin glycan by the product of the Cj1295 homopolymeric-tract-containing gene.Microbiology (Reading, England) · 2010Article
- Genetic, structural, and antigenic analyses of glycan diversity in the O-linked protein glycosylation systems of human Neisseria species.Journal of bacteriology · 2010Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The pilin glycoprotein (PilE) is the main building block of the pilus of Neisseria gonorrhoeae (gonococcus [GC]). GC pilin is known to carry a disaccharide O-glycan, which has an alphaGal attached to the O-linked GlcNAc by a 1-3 glycosidic bond. In this report, we describe the cloning and characterization of the GC gene, pilus glycosyl transferase A (pgtA), which encodes the galactosyl transferase that catalyzes the synthesis of this Gal-GlcNAc bond of pilin glycan. A homopolymeric tract of Gs (poly-G) is present in the pgtA gene of many GC strains, and this pgtA with poly-G can undergo phase variation (Pv). However, in many other GC, pgtA lacks the poly-G and is expressed constitutively without Pv. Furthermore, by screening a large number of clinical isolates, a significant correlation was observed between the presence of poly-G in pgtA and the dissemination of GC infection. Poly-G was found in pgtA in all (24 out of 24) of the isolates from patients with disseminated gonococcal infection (DGI). In contrast, for the vast majority (20 out of 28) of GC isolated from uncomplicated gonorrhea (UG) patients, pgtA lacked the poly-G. These results indicate that Pv of pgtA is likely to be involved in the conversion of UG to DGI.
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