ArticleInfection and immunity2002
Fusobacterium necrophorum leukotoxin induces activation and apoptosis of bovine leukocytes.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Genomic characterization of Fusobacterium necrophorum subsp. necrophorum strain JKSFn-26 associated with severe ovine footrot in Kashmir, India.Molecular biology reports · 2026Article
- Postpartum Uterine Diseases in Dairy Cattle: Integrating Microbiology, Immunology, and Reproductive Physiology.Microorganisms · 2026Review
- Fusobacterium necrophorum in necrotic laryngitis of feedlot cattle.Journal of veterinary internal medicine · 2026Article
- Commensal Microbiota and Reproductive Health in Livestock: Mechanisms, Cross-System Crosstalk, and Precision Strategies.Animals : an open access journal from MDPI · 2026Review
- Effects of dietary starch concentration and feeding management regimen on bacterial pathogens in liver abscesses and ruminal and colonic epithelial tissues in feedlot steers.Journal of animal science · 2026Article
- Fusobacterium in the microbiome: from health to disease across the oral-gut axis and beyond.NPJ biofilms and microbiomes · 2025Review
- Quantification of major bacterial pathogens in liver abscesses and matched ruminal and colonic epithelial tissues of feedlot cattle.Microbiology spectrum · 2025Article
- Association of pathogenic determinants of Fusobacterium necrophorum with bacteremia, and Lemierre's syndrome.Scientific reports · 2024Article
- Fusobacterium necrophorum an Underrecognized Cause of Petrous Apicitis Presenting with Gradenigo Syndrome: A Case Report.The American journal of case reports · 2024Article
- EstablishingVirulence · 2023Article
- Outer-Membrane Vesicles ofMicroorganisms · 2023Article
- Comparative Genomic Analysis of Fusobacterium necrophorum Provides Insights into Conserved Virulence Genes.Microbiology spectrum · 2022Article
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- Evaluation of Immunoprotective Effects ofFrontiers in veterinary science · 2021Article
- Utilizing WholeJournal of bacteriology · 2019Article
- Time-Course Transcriptome Analysis of Gingiva-Derived Mesenchymal Stem Cells Reveals ThatFrontiers in cell and developmental biology · 2019Article
- Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure.BMJ open diabetes research & care · 2016Article
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Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusobacterium necrophorum, a gram-negative, rod-shaped, anaerobic bacterium, is a primary or secondary etiological agent in a variety of necrotic, purulent infections in humans and animals. Its major virulence factor is leukotoxin, a high-molecular-weight secreted protein, primarily toxic to ruminant leukocytes. In this study, bovine peripheral blood leukocytes were exposed to various concentrations of immunoaffinity-purified leukotoxin and the cytotoxicity was analyzed by flow cytometry and scanning and transmission electron microscopy. At very low toxin concentrations, polymorphonuclear leukocytes (PMNs) showed activation, as indicated by translocation of primary and secondary granules to the periphery of the cytoplasm. Furthermore, these cells showed changes characteristic of apoptosis, including decreased cell size, organelle condensation, cytoplasmic membrane blebbing (zeiosis), and chromatin condensation and margination, and decrease in cellular DNA content. At moderately high concentrations of leukotoxin, bovine mononuclear cells were also induced to undergo programmed cell death. At very high concentrations, leukotoxin caused necrotic cell death of bovine peripheral leukocytes. The ability of F. necrophorum leukotoxin to modulate the host immune system by its toxicity, including cellular activation of PMNs and apoptosis-mediated killing of phagocytes and immune effector cells, represents a potentially important mechanism of its pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.