ArticleInfection and immunity2002
Helicobacter pylori-induced activation of human endothelial cells.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 95 citations in OpenAlex.
- A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology.Digestive diseases and sciences · 2005Trial
- Review
- Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease.European journal of medical research · 2024Review
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Helicobacter pylori infection selectively attenuates endothelial function in male miceFrontiers in cellular and infection microbiology · 2023Article
- Everolimus ameliorates Helicobacter pylori infection-induced inflammation in gastric epithelial cells.Bioengineered · 2022Article
- Intestinal Ischemic Manifestations of COVID-19.Gastroenterology · 2021Article
- COVID-19, coagulopathy and venous thromboembolism: more questions than answers-comment.Internal and emergency medicine · 2021Article
- Article
- Both diet and Helicobacter pylori infection contribute to atherosclerosis in pre- and postmenopausal cynomolgus monkeys.PloS one · 2019Article
- Hepatic Encephalopathy and Helicobacter pylori.Digestive diseases and sciences · 2018Article
- Article
- Association of endothelial dysfunction and cytotoxin-associated gene A-positive Helicobacter pylori in patients with cardiac syndrome X.Biomedical journal · 2016Article
- Influence of H. pylori CagA Coupled with Alcohol Consumption on Cytokine Profiles in Men.Medicine · 2016Observational
- Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion.PloS one · 2015Article
- Use of selected lactic acid bacteria in the eradication of Helicobacter pylori infection.Journal of microbiology (Seoul, Korea) · 2014Article
- Bioactivity and immunological evaluation of LPS from different serotypes of Helicobacter pylori.Iranian journal of microbiology · 2013Article
- Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats.World journal of gastroenterology · 2010Article
- Selective upregulation of endothelial E-selectin in response to Helicobacter pylori-induced gastritis.Infection and immunity · 2009Article
- Emerging role of IL-23/IL-17 axis in H pylori-associated pathology.World journal of gastroenterology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection causes active chronic inflammation with a continuous recruitment of neutrophils to the inflamed gastric mucosa. To evaluate the role of endothelial cells in this process, we have examined adhesion molecule expression and chemokine and cytokine production from human umbilical vein endothelial cells stimulated with well-characterized H. pylori strains as well as purified proteins. Our results indicate that endothelial cells actively contribute to neutrophil recruitment, since stimulation with H. pylori bacteria induced upregulation of the adhesion molecules VCAM-1, ICAM-1, and E-selectin as well as the chemokines interleukin 8 (IL-8) and growth-related oncogene alpha (GRO-alpha) and the cytokine IL-6. However, there were large variations in the ability of the different H. pylori strains to stimulate endothelial cells. These interstrain variations were seen irrespective of whether the strains had been isolated from patients with duodenal ulcer disease or asymptomatic carriers and were not solely related to the expression of known virulence factors, such as the cytotoxin-associated gene pathogenicity island, vacuolating toxin A, and Lewis blood group antigens. In addition, one or several unidentified proteins which act via NF-kappaB activation seem to induce endothelial cell activation. In conclusion, human endothelial cells produce neutrophil-recruiting factors and show increased adhesion molecule expression after stimulation with certain H. pylori strains. These effects probably contribute to the continuous recruitment of neutrophils to H. pylori-infected gastric mucosa and may also contribute to tissue damage and ulcer formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.