ArticleInfection and immunity2002
Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Leishmania amazonensis amastigotes invade non-phagocytic cells via highly localized parasite-induced actin remodeling.PLoS neglected tropical diseases · 2026Article
- New insights into the life cycle, host cell tropism, and infection amplification ofInfection and immunity · 2025Review
- Using machine learning to dissect host kinases required for Leishmania internalization and development.Molecular and biochemical parasitology · 2024Article
- Using machine learning to dissect host kinases required forbioRxiv : the preprint server for biology · 2024Article
- Unrevealing the Mystery of Latent Leishmaniasis: What Cells Can HostPathogens (Basel, Switzerland) · 2023Review
- Article
- Role of Host Small GTPases in Apicomplexan Parasite Infection.Microorganisms · 2022Review
- Causative Agents of American Tegumentary Leishmaniasis Are Able to Infect 3T3-L1 AdipocytesFrontiers in cellular and infection microbiology · 2022Article
- Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.Pathogens (Basel, Switzerland) · 2017Review
- The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.Journal of cell science · 2016Article
- Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts.Frontiers in immunology · 2016Review
- Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window.Infection and immunity · 2015Article
- Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms.Immunologic research · 2014Review
- Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold.Microbes and infection · 2014Article
- The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.Molecular and cellular biology · 2012Article
- Identification of Drosophila gene products required for phagocytosis of Leishmania donovani.PloS one · 2012Article
- The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.The Journal of biological chemistry · 2009Article
- Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis.PLoS pathogens · 2008Article
- Interactions of the streptococcal C5a peptidase with human fibronectin.Acta biomaterialia · 2008Article
- The amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection and persist.International journal for parasitology · 2007Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lesions caused by Leishmania amazonensis normally heal, but relapses occur due to parasite persistence in host tissues. It has been proposed that infection of fibroblasts plays an important role in this process by providing the parasites with a safe haven in which to replicate. However, most previous studies have focused on the entry of Leishmania into macrophages, a process mediated by serum opsonins. To gain insight into a possible role of nonopsonic entry in the intracellular persistence of amastigotes, we examined the invasion of Chinese hamster ovary (CHO) cells. Amastigotes entered CHO cells by a cytochalasin D, genistein, wortmannin, and 2,3-butanedione monoxime-sensitive pathway and replicated within phagolysosomes. However, unlike most phagocytic processes described to date, amastigote internalization in CHO cells involved activation of the GTPases Rho and Cdc42 but not Rac-1. When uptake was mediated by fibronectin or when amastigotes were opsonized with immunoglobulin G and internalized by Fc receptor-expressing CHO cells, Rac-1 activation was restored and found to be required for parasite internalization. Given the essential role of Rac in assembly of the respiratory burst oxidase, invasion through this nonopsonic, Rac-1-independent pathway may play a central role in the intracellular survival of Leishmania in immune hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.