ArticleInfection and immunity2002
Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages.PLoS pathogens · 2025Article
- Review
- What Do We Know about Surface Proteins of Chicken ParasitesLife (Basel, Switzerland) · 2023Review
- Compounds targeting GPI biosynthesis orComputational and structural biotechnology journal · 2022Article
- Unveiling the Sugary Secrets ofFrontiers in microbiology · 2021Review
- High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection.Molecular & cellular proteomics : MCP · 2019Article
- Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro.Veterinary immunology and immunopathology · 2018Article
- Characterization of the Theileria parva sporozoite proteome.International journal for parasitology · 2018Article
- Characterization of a putative Plasmodium falciparum SAC1 phosphoinositide-phosphatase homologue potentially required for survival during the asexual erythrocytic stages.Scientific reports · 2017Article
- Parasite Carbohydrate Vaccines.Frontiers in cellular and infection microbiology · 2017Review
- Sugar activation and glycosylation in Plasmodium.Malaria journal · 2015Review
- Article
- Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages of Plasmodium falciparum.The Journal of biological chemistry · 2013Article
- Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.PLoS neglected tropical diseases · 2013Article
- An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells.BMC biotechnology · 2010Article
- Plasmodium falciparum GPI mannosyltransferase-III has novel signature sequence and is functional.Biochemical and biophysical research communications · 2007Article
- Plasmodium vivax: paroxysm-associated lipids mediate leukocyte aggregation.Malaria journal · 2007Article
- Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols.Infection and immunity · 2006Article
- Malaria tolerance--for whom the cell tolls?Trends in parasitology · 2006Review
- Crystal structure of the conserved protein TT1542 from Thermus thermophilus HB8.Protein science : a publication of the Protein Society · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
About 2.5 million people die of Plasmodium falciparum malaria every year. Fatalities are associated with systemic and organ-specific inflammation initiated by a parasite toxin. Recent studies show that glycosylphosphatidylinositol (GPI) functions as the dominant parasite toxin in the context of infection. GPIs also serve as membrane anchors for several of the most important surface antigens of parasite invasive stages. GPI anchoring is a complex posttranslational modification produced through the coordinated action of a multicomponent biosynthetic pathway. Here we present eight new genes of P. falciparum selected for encoding homologs of proteins essential for GPI synthesis: PIG-A, PIG-B, PIG-M, PIG-O, GPI1, GPI8, GAA-1, and DPM1. We describe the experimentally verified mRNA and predicted amino acid sequences and in situ localization of the gene products to the parasite endoplasmic reticulum. Moreover, we show preliminary evidence for the PIG-L and PIG-C genes. The biosynthetic pathway of the malaria parasite GPI offers potential targets for drug development and may be useful for studying parasite cell biology and the molecular basis for the pathophysiology of parasitic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.