Trial reportGut2002
Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans.
Trial report in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 211 citations in OpenAlex.
- Gastric Biofeedback in Virtual Reality: Feasibility, Efficacy and Self-Reported Experience.Applied psychophysiology and biofeedback · 2026Trial
- Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Trial
- Effects of intragastric L-arginine administration on proximal stomach tone under basal conditions and after an intragastric diet.Digestive diseases and sciences · 2006Trial
- The Role of Diet in Functional Dyspepsia.Nutrients · 2026Review
- Comparative study of the role of nitric oxide in the regulation of food intake across vertebrates.Journal of veterinary science · 2026Review
- Article
- Evaluation of Gastric Peristalsis Using Cine MRI in Healthy Subjects and Patients With Functional Dyspepsia.Clinical and translational gastroenterology · 2025Article
- Current Concepts in Gastroparesis and Gastric Neuromuscular Disorders-Pathophysiology, Diagnosis, and Management.Diagnostics (Basel, Switzerland) · 2025Review
- Cellular and molecular mechanisms underlying aging-related gastric neuromuscular dysfunction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- Comprehensive Treatment of Functional Dyspepsia Using Traditional Chinese Medicine: A Review Based on Pathophysiological Perspectives.Drug design, development and therapy · 2025Review
- Acupuncture and moxibustion intervention in functional dyspepsia: Gastric and duodenal regulation.Heliyon · 2024Review
- Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach.Scientific reports · 2023Article
- Defining the Molecular Mechanisms of the Relaxant Action of Adiponectin on Murine Gastric Fundus Smooth Muscle: Potential Translational Perspectives on Eating Disorder Management.International journal of molecular sciences · 2023Article
- Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community.Cardiovascular diabetology · 2022Article
- Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.The Journal of physiology · 2022Article
- Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia.Journal of neurogastroenterology and motility · 2022Article
- Lipopolysaccharide-induced inflammation increases nitric oxide production in taste buds.Brain, behavior, and immunity · 2022Article
- Article
- Homeostatic regulation of food intake.Clinics and research in hepatology and gastroenterology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIn humans, impaired gastric accommodation is associated with early satiety and weight loss. In animals, accommodation involves activation of gastric nitrergic neurones. Our aim was to study involvement of nitric oxide in gastric accommodation and in meal induced satiety in humans.
methodsThe effect of N(G)-monomethyl-L-arginine (L-NMMA) 4 mg/kg/h and 8 mg/kg/h on gastric compliance, on sensitivity to distension, and on gastric accommodation was studied with a barostat in double blind, randomised, placebo controlled studies. The effect of L-NMMA 8 mg/kg/h on meal induced satiety was studied using a drinking test.
resultsL-NMMA had no significant effect on fasting compliance and sensitivity. Ingestion of a meal induced a relaxation of 274 (15) ml which was significantly smaller after L-NMMA 4 mg/kg/h (132 (45) ml; p=0.03) or L-NMMA 8 mg/kg/h (82 (72) ml; p=0.03). L-NMMA 8 mg/kg/h significantly decreased the amount of food ingested at maximum satiety from 1058 (67) to 892 (73) kcal (p<0.01).
conclusionIn humans, fasting gastric tone and sensitivity to distension are not influenced by nitric oxide synthase inhibition, but the gastric accommodation reflex involves activation of nitrergic neurones. Inhibition of nitric oxide synthase impairs accommodation and enhances meal induced satiety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.