ArticleGut2002
Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Differentiation grade is highly concordant between matched primary and metastatic colorectal cancer.Clinical & experimental metastasis · 2025Article
- Benchmark for establishment of organoids from gastrointestinal epithelium and cancer based on available consumables and reagents.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023Article
- Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.Scientific reports · 2023Article
- Cancer-Associated Fibroblasts and Squamous Epithelial Cells Constitute a Unique Microenvironment in a Mouse Model of Inflammation-Induced Colon Cancer.Frontiers in oncology · 2022Article
- A qualitative transcriptional signature for determining the grade of colorectal adenocarcinoma.Cancer gene therapy · 2020Article
- Article
- Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells.Cancers · 2019Article
- Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation.Oncotarget · 2016Article
- A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.Cell reports · 2014Article
- Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.PloS one · 2012Article
- The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair.BMC gastroenterology · 2011Article
- IGFBP-rP1, a potential molecule associated with colon cancer differentiation.Molecular cancer · 2010Article
- Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6.Journal of cellular biochemistry · 2008Article
- Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence.Journal of cancer research and clinical oncology · 2008Article
- Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors.Virchows Archiv : an international journal of pathology · 2007Review
- Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based assay.Medical microbiology and immunology · 2006Article
- Article
- CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors.Virchows Archiv : an international journal of pathology · 2004Article
- Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- CDX2 immunoreactivity in primary and metastatic ovarian mucinous tumours.Virchows Archiv : an international journal of pathology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Cdx genes are expressed in the colorectal epithelium and are frequently downregulated during tumorigenesis. Overexpression of Cdx genes has been shown previously to result in cellular differentiation.
aimTo study expression of CDX2 in normal and neoplastic human colon using a newly isolated monoclonal antibody. To define expression of CDX1 and CDX2 in an in vitro model system of colorectal tumour progression and to ascertain whether these are subject to regulation during differentiation.
methodsNormal and neoplastic human colon was immunostained for CDX2. CDX1 and CDX2 expression was assayed in cell lines derived from premalignant colonic adenomas by western blotting. Differentiation was induced by sodium butyrate treatment or post confluent growth, and changes in CDX expression compared with carcinoma cell lines with low levels of CDX expression.
resultsCDX2 protein displayed no gradient of expression within the colonic crypt. Cell lines derived from adenomas, with high levels of CDX1 and CDX2, showed no regulation of these proteins when induced to differentiate by butyrate or confluency. CDX expression in these cell lines was independent of their APC or Ras status. CDX1 and CDX2 were expressed at very low levels in some carcinoma cell lines and were modestly upregulated on differentiation but were not restored to levels seen in adenoma cells.
conclusionThe lack of significant regulation on cellular differentiation and the absence of a detectable gradient in the crypt implies that CDX2 may confer tissue specificity but may not play the previously suggested role in crypt patterning.
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