ArticleDevelopment (Cambridge, England)2002
Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC.
Article in Development (Cambridge, England), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Development and regeneration of Merkel cells.Current topics in developmental biology · 2025Review
- TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused byInternational journal of molecular sciences · 2022Article
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Developing a sense of touch.Development (Cambridge, England) · 2017Review
- Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis.Development (Cambridge, England) · 2015Article
- Article
- The anatomy, function, and development of mammalian Aβ low-threshold mechanoreceptors.Frontiers in biology · 2013Article
- Rodents rely on Merkel cells for texture discrimination tasks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Peripheral somatosensation: a touch of genetics.Current opinion in genetics & development · 2011Review
- Merkel cells are essential for light-touch responses.Science (New York, N.Y.) · 2009Article
- Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice.The Journal of comparative neurology · 2008Article
- Voltage-activated ion channels and Ca(2+)-induced Ca (2+) release shape Ca (2+) signaling in Merkel cells.Pflugers Archiv : European journal of physiology · 2008Article
- Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Article
- TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells.The Journal of comparative neurology · 2004Article
- Molecular profiling reveals synaptic release machinery in Merkel cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The specification and wiring of mammalian cutaneous low-threshold mechanoreceptors.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
This study demonstrates that innervation dependent on two different neurotrophin tyrosine kinase (trk) receptors can form the same types of sensory endings (Merkel endings) in the same target (Merkel cells of vibrissa follicles). Some endings transiently express trkA during their initial development, whereas others express trkC throughout their development. Consequently, elimination of kinase domains of either trkA or trkC each result in a partial loss of Merkel endings, whereas absence of kinase domains of both receptors results in a total loss. At the onset of Merkel ending development, at least one kinase-lacking trkC isoform is transiently expressed on all the follicle cells, while neurotrophin 3 is transiently expressed only in the cells at the middle third of the follicle where the Merkel endings and cells develop. This transient non-neuronal expression of truncated trkC is essential for development of any Merkel endings, whereas some Merkel endings and cells still begin to develop in the absence of neurotrophin 3. Therefore, truncated trkC plays a more important role in the development of this innervation than kinase forms of trkA or trkC or of NT3, the only known ligand for trkC receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.