ArticleEndocrine pathology2000
Immunocytochemical Localization of Prohormone Convertase 1/3 and 2 in Thyroid C-Cells and Medullary Thyroid Carcinomas.
Article in Endocrine pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells.Internal medicine (Tokyo, Japan) · 2024Article
- Significance of chromogranin A and synaptophysin in medullary thyroid carcinoma.Bosnian journal of basic medical sciences · 2021Article
- Expression and localization of prohormone convertase PC1 in the calcitonin-producing cells of the bullfrog ultimobranchial gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2003Article
- Neuroendocrine secretory protein 7B2: structure, expression and functions.The Biochemical journal · 2001Review
- Immunocytochemical localization of prohormone convertase 1/3 and 2 in gastrointestinal carcinoids.Endocrine pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prohormone convertases (PCs) are the key enzymes in the regulated pathways for the post-translational processing of peptide hormones and are involved in converting larger prohormones to smaller, biologically active hormones. Immunolocalization of PC1/3 and PC2 was performed with thyroid C-cells from normal thyroid glands and medullary thyroid carcinomas (MTCs); thyroid C-cells were not consistently positive for PCs, whereas MTCs were consistently positive for PCs. Positive staining for PCs included tumor cell nests adjacent to the main MTCs in cases of multiple endocrine neoplasia type 2. Procalcitonin was originally detected in MTCs and a large amount of procalcitonin was present together with abundant PCs in MTCs. Thus, immunocytochemical staining for PCs may be another characteristic of MTCs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.