ArticleEndocrine pathology1999
Composite Pheochromocytoma-Ganglioneuroma of the Adrenal Gland: An Uncommon Entity with Distinctive Clinicopathologic Features.
Article in Endocrine pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presentation and outcomes of adrenal ganglioneuromas: A cohort study and a systematic review of literature.Clinical endocrinology · 2021Pooled it
- Composite pheochromocytoma of the adrenal gland-a review of published cases.Virchows Archiv : an international journal of pathology · 2023Review
- Composite Paraganglioma of the Celiac Trunk: A Case Report and a Comprehensive Review of the Literature.Frontiers in surgery · 2022Review
- Composite pheochromocytoma/paraganglioma-ganglioneuroma: analysis of SDH and ATRX status, and identification of frequent HRAS and BRAF mutations.Endocrine connections · 2021Article
- Clinical profiles of patients with surgically resected pheochromocytoma and paraganglioma.The Korean journal of internal medicine · 2020Article
- A Novel MAX Gene Mutation Variant in a Patient With Multiple and "Composite" Neuroendocrine-Neuroblastic Tumors.Frontiers in endocrinology · 2020Article
- A Guide to Pheochromocytomas and Paragangliomas.Surgical pathology clinics · 2019Review
- Composite Pheochromocytoma/Paraganglioma-Ganglioneuroma: A Clinicopathologic Study of Eight Cases with Analysis of Succinate Dehydrogenase.Endocrine pathology · 2017Article
- Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.Endocrine pathology · 2017Review
- A rare and easily misdiagnosed tumor of the urinary bladder: primary composite pheochromocytoma.International journal of clinical and experimental pathology · 2017Article
- Diverse proportion in composite pheochromocytoma-ganglioneuroma may induce varied clinical symptom: comparison of two cases.International journal of clinical and experimental pathology · 2015Article
- Adrenal oncocytic phaeochromocytoma with putative adverse histologic features: a unique case report and review of the literature.Endocrine pathology · 2014Review
- Retroperitoneal composite pheochromocytoma-ganglioneuroma : a case report and review of literature.Diagnostic pathology · 2013Review
- Partial adrenalectomy minimizes the need for long-term hormone replacement in pediatric patients with pheochromocytoma and von Hippel-Lindau syndrome.Journal of pediatric surgery · 2012Article
- Composite pheochromocytoma.South Asian journal of cancer · 2012Article
- Composite adrenal medullary tumor: A rare cause of hypertension in a young male.Urology annals · 2011Article
- Radiological and pathological findings of a metastatic composite paraganglioma with neuroblastoma in a man: a case report.Journal of medical case reports · 2010Article
- Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass.Endocrine pathology · 2009Article
- Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene.Journal of endocrinological investigation · 2005Article
- Sporadic type composite pheochromocytoma with neuroblastoma: clinicomorphologic, DNA content and ret gene analysis.Endocrine pathology · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adrenal composite pheochromocytoma-ganglioneuroma is uncommon. The aim of this study is to investigate the characteristics of patients with this tumor. Methods: Histologic features of 46 pheochromocytomas diagnosed over a 28-year period (1971-1998) were reviewed. The clinical records, pathologic features, and ploidy patterns of patients with composite pheochromocytoma-ganglioneuroma were studied. Cases reported in the literature were also reviewed and compared with typical pheochromocytomas. Results: Four patients (two men; two women) with composite pheochromocytoma-ganglioneuromas were found. The tumors comprised 8.7% of pheochromocytomas. The two male patients with composite tumors were younger than the two female patients (age = 32, 52 vs 73, 75, respectively). The radiologic, gross, and microscopic appearances of the tumors were heterogeneous. One patient had malignant tumor with distant metastases. Flow cytometric analysis showed that the pheochromocytoma component was aneuploid and the ganglioneuroma portion was diploid. A review of the literature showed 31 adrenal composite pheochromocytoma-ganglioneuromas. Composite tumors were seen in older patients and were bigger than typical pheochromocytomas. Conclusion: Composite pheochromocytoma-ganglioneuromas had distinctive clinicopathologic features. Life-long clinical and biochemical follow-up of these patients is essential in view of the non-diploid DNA pattern.
Identifiers
12114771What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.