ArticleEndocrine pathology2000
Effect of Dopamine Agonists on Lactotroph Adenomas of the Human Pituitary.
Article in Endocrine pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- The microenvironment of pituitary adenomas: biological, clinical and therapeutical implications.Pituitary · 2022Review
- Article
- Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Review
- Pituitary gland: can prolactinomas be cured medically?Nature reviews. Endocrinology · 2010Article
- Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissue.Neurosurgical review · 2008Review
- Remission of acromegaly following long-term therapy with cabergoline: report of two cases.Pituitary · 2008Article
- Fractal dimension as a quantitator of the microvasculature of normal and adenomatous pituitary tissue.Journal of anatomy · 2007Article
- Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat.Virchows Archiv : an international journal of pathology · 2007Article
- [Effects of irradiation therapy and inhibiting drugs on the pituitary and its adenomas].Der Pathologe · 2006Article
- Classification and pathology of pituitary tumors.Endocrine · 2005Review
- Pharmacologic resistance in prolactinoma patients.Pituitary · 2005Review
- Dopamine resistance of prolactinomas.Pituitary · 2003Review
- Decrease of Proliferative Potential and Vascular Density of Giant Prolactinoma in Patients Treated with Cabergoline.Asian journal of neurosurgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine (DA) agonists cause reduction of blood prolactin level and tumor shrinkage in most patients with lactotroph adenoma. Our aim was to investigate the cellular mechanism of tumor shrinkage by determining mitotic, MIB-1, p27, and apoptotic indices, as well as microvessel density (MVD), surface microvessel density (SMD). ploidy, and other nuclear parameters. Surgically removed lactotroph adenomas were selected from 29 patients, of whom 19 were treated with oral bromocriptine (BEC), long-acting injectable BEC (BEC-LAR), or quinagolide and 10 were untreated. In treated adenomas mitotic and MIB-1 indices were lower, whereas the apoptotic indices were not significantly higher compared to untreated adenomas. The decrease in MIB-1 labeling reached significance in adenomas exposed to quinagolide (p<0.05). Aside from the BEC-LAR treated group, wherein p27 expression was significantly reduced (p<0.05), p27 expression did not differ significantly between the treated and untreated groups. MVD density was significantly lower in the treated adenomas, whereas the decrease in SMD did not attain significance. The DNA ploidy and most other nuclear parameters did not differ significantly in the two groups. In conclusion, reduction of mitotic and MIB-1 indices indicates that suppression of cell proliferation contributes to tumor shrinkage, whereas p27 protein expression and apoptosis play no major role in the adenoma involution. Further studies are required to explain the effect of DA agonists on MVD and SMD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.