ArticleEndocrine pathology2002
Expression of E-cadherin, b-catenin, and Ki-67 in goblet cell carcinoids of the appendix: an immunohistochemical study with clinical correlation.
Article in Endocrine pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report.Annals of coloproctology · 2024Article
- Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry.Frontiers in oncology · 2022Article
- Article
- Goblet cell carcinoid of the appendix: Case report of a high grade tumor in a 20-year-old.International journal of surgery case reports · 2018Article
- Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.World journal of surgical oncology · 2015Review
- Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case.Surgery today · 2011Article
- Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review.World journal of gastroenterology · 2011Article
- Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix.Pathology oncology research : POR · 2011Article
- Goblet cell carcinoid tumors of the appendix: An overview.World journal of gastrointestinal oncology · 2010Article
- Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms.Virchows Archiv : an international journal of pathology · 2007Review
- Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix.Endocrine pathology · 2007Article
- Expression of beta-catenin in gastroenteropancreatic endocrine tumours: a study of 229 cases.Journal of clinical pathology · 2006Article
- A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression.Virchows Archiv : an international journal of pathology · 2005Article
- Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid).World journal of surgery · 2005Article
- Goblet cell carcinoid of the appendix.World journal of surgical oncology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Goblet cell carcinoid (GCC) of the appendix is a rare entity, of which both the histogenesis and biologic behavior remain controversial, and prognostic tools and therapeutic strategies for this unusual tumor have yet to be defined. The aim of this study was to analyze expression of E-cadherin and b-catenin in GCCs of the appendix with long-term follow-up data as related to the expression of Ki-67 proliferation marker to provide a rationale for treatment guidelines. We analyzed the expression of E-cadherin, b-catenin, and Ki-67 in 11 GCCs of the appendix and control groups of typical carcinoids of the large intestine (n = 29), well to moderately differentiated adenocarcinomas of the colon (n = 10), poorly differentiated adenocarcinomas of the colon (n = 12), and normal appendiceal tissues (n = 10). There was no significant difference between the GCCs and normal appendiceal tissues regarding the expression of E-cadherin or b-catenin (p = 0.297 and 0.103, respectively). The percentage of positive GCC cells ranged between 0.52 and 10.35% (4.27 +/- 0.80), and only one case had a score >10%. Metastatic tumor spread and death were found in high MIB-1 labeling index (LI) cases of GCC (>3%). Our findings suggest that the behavior of the majority of GCCs might be indolent and different from adenocarcinomas because of the preserved expression of E-cadherin and b-catenin and relatively low MIB-1 LI. However, some of these tumors act aggressively and MIB-1 LI might be a good parameter to determine the therapeutic procedure.
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