ArticleEndocrine pathology1995
Amyloid Deposits in Pituitaries and Pituitary Adenomas: Immunohistochemistry and In Situ Hybridization.
Article in Endocrine pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.Human molecular genetics · 2018Article
- Clinical Impact of the Current WHO Classification of Pituitary Adenomas.Endocrine pathology · 2016Review
- Pituicytoma with gelsolin amyloid deposition.Endocrine pathology · 2013Article
- Prolactin is an amyloid-related protein.Journal of endocrinological investigation · 2004Article
- [Pituitary gland tumors].Der Pathologe · 2003Review
- Amyloid in surgical pathology.Virchows Archiv : an international journal of pathology · 2003Review
- Prolactin-derived amyloid in the aging pituitary gland.The American journal of pathology · 1997Article
- Investigation of the Presence of Apotipoprotein E, G lycosaminoglycans, Basement Membrane Proteins, and Protease inhibitors in Senile interstitial Amyloid of the Pituitary.Endocrine pathology · 1997Article
- Senile amyloidoses of the pituitary and adrenal glands. Morphological and statistical investigations.Virchows Archiv : an international journal of pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The patterns of deposition and immunoreactivity of interstitial amyloid were studied in 11 pituitary glands obtained at autopsy and 9 surgically resected pituitary adenomas using Congo red staining and a panel of antisera directed against 5 major amyloid fibril proteins and all pituitary hormones. The deposition pattern of amyloid in pituitary glands differed from that in adenomas but all amyloid deposits showed an immunostaining with anti-amyloid X-light chain. The remaining antisera were immunonegative. In situ hybridization using an oligodeoxyribonucleotide-probe complementary to the mRNA coding for the constant region of human X-light chain yielded no hybridization signals in the pituitaries or pituitary adenomas, excluding local synthesis and secretion of immunoglobulins. Since no case studied suffered from generalized AX-amyloidosis and adsorption of immunoglobulins to the unknown amyloid fribril protein of the pituitary seems to be unlikely, crossreaction of the polyclonal antisera with an undefined antigen is probable. The similar immunostaining properties of amyloid deposits in "normal" pituitaries and pituitary adenomas suggest they both originate from the same precursor protein.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.