ArticlePlant physiology2002
Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 192 citations in OpenAlex.
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- Estimating sorghum leaf dhurrin content using a handheld near infrared instrument.Frontiers in plant science · 2026Article
- Germination-induced cyanide accumulation during the grain hydration process ofFood chemistry: X · 2025Article
- Genome-Wide Identification and Transcriptome Analysis of P450 Superfamily Genes in Flax (International journal of molecular sciences · 2025Article
- Saline irrigation improves survival of forage sorghum but limits growth and increases toxicity.Plant biology (Stuttgart, Germany) · 2025Article
- Dhurrin: a potential endogenous nitrogen turnover source for early seedling growth in sorghum.Frontiers in plant science · 2025Article
- Abiotic stress responses in forage crops and grasses: the role of secondary metabolites and biotechnological interventions.Frontiers in plant science · 2025Review
- Plant cyanogenic glycosides: from structure to properties and potential applications.Frontiers in plant science · 2025Review
- Dhurrin in Sorghum: Biosynthesis, Regulation, Biological Function and Challenges for Animal Production.Plants (Basel, Switzerland) · 2024Review
- The Putative GATA Transcription FactorLife (Basel, Switzerland) · 2024Article
- Deciphering the Genetic Mechanisms of Salt Tolerance inPlants (Basel, Switzerland) · 2023Article
- Recruitment of distinct UDP-glycosyltransferase families demonstrates dynamic evolution of chemical defense within Eucalyptus L'Hér.The New phytologist · 2023Article
- Seedling growth and fall armyworm feeding preference influenced by dhurrin production in sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Article
- Cyanogenesis in theGenes · 2022Article
- Article
- Metabolomic Study of Sorghum (Journal of agricultural and food chemistry · 2021Article
- Allocation of Resources to Cyanogenic Glucosides Does Not Incur a Growth Sacrifice inPlants (Basel, Switzerland) · 2020Article
- Prediction of Dhurrin Metabolism by Transcriptome and Metabolome Analyses inPlants (Basel, Switzerland) · 2020Article
- Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination.Plant physiology · 2020Article
Corrections and comments
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2 authors.
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Abstract
The content of the cyanogenic glucoside dhurrin in sorghum (Sorghum bicolor L. Moench) varies depending on plant age and growth conditions. The cyanide potential is highest shortly after onset of germination. At this stage, nitrogen application has no effect on dhurrin content, whereas in older plants, nitrogen application induces an increase. At all stages, the content of dhurrin correlates well with the activity of the two biosynthetic enzymes, CYP79A1 and CYP71E1, and with the protein and mRNA level for the two enzymes. During development, the activity of CYP79A1 is lower than the activity of CYP71E1, suggesting that CYP79A1 catalyzes the rate-limiting step in dhurrin synthesis as has previously been shown using etiolated seedlings. The site of dhurrin synthesis shifts from leaves to stem during plant development. In combination, the results demonstrate that dhurrin content in sorghum is largely determined by transcriptional regulation of the biosynthetic enzymes CYP79A1 and CYP71E1.
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