ArticlePlant physiology2002
Distinct physiological roles of fructokinase isozymes revealed by gene-specific suppression of Frk1 and Frk2 expression in tomato.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 116 citations in OpenAlex.
- Pan-Genome Analysis of the Fructokinase Gene Family Reveals a Light-Regulated SiPhyC-SiFRK4 Module Controlling Carbon Partitioning in Foxtail Millet.Plants (Basel, Switzerland) · 2026Article
- Mango Fructokinases Inhibit Sugar Accumulation and Enhance Energy Metabolism in Transgenic Tomato.Plants (Basel, Switzerland) · 2025Article
- Alternative splicing occurs in auxin-mediated trade-off between fruit development and quality in tomato.BMC plant biology · 2025Article
- Transgenerational Seed Exposure to Elevated COACS omega · 2024Article
- The AlkB Homolog SlALKBH10B Negatively Affects Drought and Salt Tolerance inInternational journal of molecular sciences · 2023Article
- PANTOTHENATE KINASE4, LOSS OF GDU2, and TRANSPOSON PROTEIN1 affect the canalization of tomato fruit metabolism.Plant physiology · 2023Article
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- Calcyclin-binding protein-promoted degradation of MdFRUCTOKINASE2 regulates sugar homeostasis in apple.Plant physiology · 2023Article
- A Comparative Characterization and Expression Profiling Analysis ofInternational journal of molecular sciences · 2022Article
- Article
- The metabolic changes that effect fruit quality during tomato fruit ripening.Molecular horticulture · 2022Review
- Guard cells control hypocotyl elongation through HXK1, HY5, and PIF4.Communications biology · 2021Article
- Physiological and Proteomic Analyses of Two Acanthus Species to Tidal Flooding Stress.International journal of molecular sciences · 2021Article
- Integrated Methylome and Transcriptome Analyses Reveal the Molecular Mechanism by Which DNA Methylation Regulates Kenaf Flowering.Frontiers in plant science · 2021Article
- Proteomic and Transcriptomic Analyses Indicate Metabolic Changes and Reduced Defense Responses in Mycorrhizal Roots ofJournal of fungi (Basel, Switzerland) · 2020Article
- Two glyoxylate reductase isoforms are functionally redundant but required under high photorespiration conditions in rice.BMC plant biology · 2020Article
- Evolution and Functional Divergence of theFrontiers in plant science · 2020Article
- Tomato Fruit Development and Metabolism.Frontiers in plant science · 2019Review
- Melatonin-Mediated Sugar Accumulation and Growth Inhibition in Apple Plants Involves Down-Regulation of Fructokinase 2 Expression and Activity.Frontiers in plant science · 2019Article
- A Quantitative Proteomics View on the Function ofPathogens (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are two divergent fructokinase isozymes, Frk1 and Frk2 in tomato (Lycopersicon esculentum Mill.) plants. To investigate the physiological functions of each isozyme, the expression of each fructokinase mRNA was independently suppressed in transgenic tomato plants, and the respective phenotypes were evaluated. Suppression of Frk1 expression resulted in delayed flowering at the first inflorescence. Suppression of Frk2 did not effect flowering time but resulted in growth inhibition of stems and roots, reduction of flower and fruit number, and reduction of seed number per fruit. Localization of Frk1 and Frk2 mRNA accumulation by in situ hybridization in wild-type tomato fruit tissue indicated that Frk2 is expressed specifically in early tomato seed development. Fruit hexose and starch content were not effected by the suppression of either Frk gene alone. The results collectively indicate that flowering time is specifically promoted by Frk1 and that Frk2 plays specific roles in contributing to stem and root growth and to seed development. Because Frk1 and Frk2 gene expression was suppressed individually in transgenic plants, other significant metabolic roles of fructokinases may not have been observed if Frk1 and Frk2 play, at least partially, redundant metabolic roles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.