ArticleThe Journal of biological chemistry2002
Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.
Article in The Journal of biological chemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- An Update on Protein Kinases as Therapeutic Targets-Part II: Peptides as Allosteric Protein Kinase C Modulators Targeting Protein-Protein Interactions.International journal of molecular sciences · 2023Review
- Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase.Cell communication and signaling : CCS · 2016Article
- MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.Frontiers in bioscience (Landmark edition) · 2009Review
- The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages.Journal of leukocyte biology · 2008Article
- TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.Advances in cancer research · 2008Review
- Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells.Journal of molecular medicine (Berlin, Germany) · 2007Article
- Article
- Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly.American journal of respiratory cell and molecular biology · 2005Article
- Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2004Article
- Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes.American journal of respiratory cell and molecular biology · 2004Article
- Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction.Molecular neurobiology · 2004Review
- The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages.Journal of leukocyte biology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We showed previously that protein kinase C (PKC) is required for phagocytosis of apoptotic leukocytes by murine alveolar (AMø) and peritoneal macrophages (PMø) and that such phagocytosis is markedly lower in AMø compared with PMø. In this study, we examined the roles of individual PKC isoforms in phagocytosis of apoptotic thymocytes by these two Mø populations. By immunoblotting, AMø expressed equivalent PKC eta but lower amounts of other isoforms (alpha, betaI, betaII, delta, epsilon, mu, and zeta), with the greatest difference in betaII expression. A requirement for PKC betaII for phagocytosis was demonstrated collectively by phorbol 12-myristate 13-acetate-induced depletion of PKC betaII, by dose-response to PKC inhibitor Ro-32-0432, and by use of PKC betaII myristoylated peptide as a blocker. Exposure of PMø to phosphatidylserine (PS) liposomes specifically induced translocation of PKC betaII and other isoforms to membranes and cytoskeleton. Both AMø and PMø expressed functional PS receptor, blockade of which inhibited PKC betaII translocation. Our results indicate that murine tissue Mø require PKC betaII for phagocytosis of apoptotic cells, which differs from the PKC isoform requirement previously described in Mø phagocytosis of other particles, and imply that a crucial action of the PS receptor in this process is PKC betaII activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.