ArticleAmerican journal of human genetics2002
Powerful regression-based quantitative-trait linkage analysis of general pedigrees.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
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Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomewide linkage scans for ocular refraction and meta-analysis of four populations in the Myopia Family Study.Investigative ophthalmology & visual science · 2009Pooled it
- A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs.Molecular psychiatry · 2006Trial
- Identification of Nuclear Genetic Loci Linked to Clinical Features of the m.3243A>G Mitochondrial DNA Variant.Neurology. Genetics · 2026Article
- A fast linkage method for population GWAS cohorts with related individuals.Genetic epidemiology · 2023Article
- Network-based quantitative trait linkage analysis of microbiome composition in inflammatory bowel disease families.Frontiers in genetics · 2023Article
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
- Statistical Methods and Software for Substance Use and Dependence Genetic Research.Current genomics · 2019Review
- Novel caries loci in children and adults implicated by genome-wide analysis of families.BMC oral health · 2018Article
- A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2017Article
- Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.Journal of insect physiology · 2016Article
- Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study.Schizophrenia research · 2016Review
- Quantitative linkage for autism spectrum disorders symptoms in attention-deficit/hyperactivity disorder: significant locus on chromosome 7q11.Journal of autism and developmental disorders · 2014Article
- LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS.The annals of applied statistics · 2014Article
- Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression.Frontiers in genetics · 2014Article
- Heritability and linkage analysis of personality in bipolar disorder.Journal of affective disorders · 2013Article
- Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.Journal of affective disorders · 2013Article
- Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2013Article
- Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea.Journal of Korean medical science · 2013Article
- A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees.Advances in genetics · 2013Article
- Genome-wide linkage analysis of human auditory cortical activation suggests distinct loci on chromosomes 2, 3, and 8.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
60 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
We present a new method of quantitative-trait linkage analysis that combines the simplicity and robustness of regression-based methods and the generality and greater power of variance-components models. The new method is based on a regression of estimated identity-by-descent (IBD) sharing between relative pairs on the squared sums and squared differences of trait values of the relative pairs. The method is applicable to pedigrees of arbitrary structure and to pedigrees selected on the basis of trait value, provided that population parameters of the trait distribution can be correctly specified. Ambiguous IBD sharing (due to incomplete marker information) can be accommodated in the method by appropriate specification of the variance-covariance matrix of IBD sharing between relative pairs. We have implemented this regression-based method and have performed simulation studies to assess, under a range of conditions, estimation accuracy, type I error rate, and power. For normally distributed traits and in large samples, the method is found to give the correct type I error rate and an unbiased estimate of the proportion of trait variance accounted for by the additive effects of the locus-although, in cases where asymptotic theory is doubtful, significance levels should be checked by simulations. In large sibships, the new method is slightly more powerful than variance-components models. The proposed method provides a practical and powerful tool for the linkage analysis of quantitative traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.