ArticleBritish journal of pharmacology2002
K+-induced hyperpolarization in rat mesenteric artery: identification, localization and role of Na+/K+-ATPases.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 80 citations in OpenAlex.
- Activation of Smooth Muscle KInternational journal of molecular sciences · 2025Article
- Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage.EBioMedicine · 2024Article
- Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation.Frontiers in physiology · 2022Review
- Comparisons between perivascular adipose tissue and the endothelium in their modulation of vascular tone.British journal of pharmacology · 2017Review
- Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.Microcirculation (New York, N.Y. : 1994) · 2015Review
- Na+/Ca2+ exchange and Na+/K+-ATPase in the heart.The Journal of physiology · 2015Review
- Article
- Effect of phenylephrine and endothelium on vasomotion in rat aorta involves potassium uptake.The journal of physiological sciences : JPS · 2013Article
- Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta.BMC physiology · 2012Article
- K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.Frontiers in pharmacology · 2012Article
- Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling.British journal of pharmacology · 2011Article
- EDHF: spreading the influence of the endothelium.British journal of pharmacology · 2011Review
- Smooth muscle Ca(2+) -activated and voltage-gated K+ channels modulate conducted dilation in rat isolated small mesenteric arteries.Microcirculation (New York, N.Y. : 1994) · 2011Article
- Regulation of cerebral blood flow.International journal of vascular medicine · 2011Article
- Modeling Ca2+ signaling in the microcirculation: intercellular communication and vasoreactivity.Critical reviews in biomedical engineering · 2011Review
- Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation.American journal of physiology. Heart and circulatory physiology · 2011Article
- Impairment of endothelial SK(Ca) channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats.British journal of pharmacology · 2010Article
- Endothelium-derived hyperpolarising factors and associated pathways: a synopsis.Pflugers Archiv : European journal of physiology · 2010Review
- A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication.Microcirculation (New York, N.Y. : 1994) · 2009Article
- Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats.Translational research : the journal of laboratory and clinical medicine · 2009Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Mechanisms underlying K(+)-induced hyperpolarizations in the presence and absence of phenylephrine were investigated in endothelium-denuded rat mesenteric arteries (for all mean values, n=4). 2. Myocyte resting membrane potential (m.p.) was -58.8+/-0.8 mV. Application of 5 mM KCl produced similar hyperpolarizations in the absence (17.6+/-0.7 mV) or presence (15.8+/-1.0 mV) of 500 nM ouabain. In the presence of ouabain +30 microM barium, hyperpolarization to 5 mM KCl was essentially abolished. 3. In the presence of 10 microM phenylephrine (m.p. -33.7+/-3 mV), repolarization to 5 mM KCl did not occur in the presence or absence of 4-aminopyridine but was restored (-26.9+/-1.8 mV) on addition of iberiotoxin (100 nM). Under these conditions the K+-induced repolarization was insensitive to barium (30 microM) but abolished by 500 nM ouabain alone. 4. In the presence of phenylephrine + iberiotoxin the hyperpolarization to 5 mM K(+) was inhibited in the additional presence of 300 nM levcromakalim, an action which was reversed by 10 microM glibenclamide. 5. RT-PCR, Western blotting and immunohistochemical techniques collectively showed the presence of alpha(1)-, alpha(2)- and alpha(3)-subunits of Na(+)/K(+)-ATPase in the myocytes. 6. In K(+)-free solution, re-introduction of K(+) (to 4.6 mM) hyperpolarized myocytes by 20.9+/-0.5 mV, an effect unchanged by 500 nM ouabain but abolished by 500 microM ouabain. 7. We conclude that under basal conditions, Na(+)/K(+)-ATPases containing alpha(2)- and/or alpha(3)-subunits are partially responsible for the observed K(+)-induced effects. The opening of myocyte K(+) channels (by levcromakalim or phenylephrine) creates a 'K(+) cloud' around the cells which fully activates Na(+)/K(+)-ATPase and thereby abolishes further responses to [K(+)](o) elevation.
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