ArticleBritish journal of pharmacology2002
FcepsilonRI cross-linking-induced actin assembly mediates calcium signalling in RBL-2H3 mast cells.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 48 citations in OpenAlex.
- Suppression of FcεRI-evoked Degranulation in RBL-2H3 Cells on Gelatin Methacryloyl Hydrogel.Cell biochemistry and biophysics · 2025Article
- STIM Proteins and Regulation of SOCE in ER-PM Junctions.Biomolecules · 2022Review
- Mast cell granule motility and exocytosis is driven by dynamic microtubule formation and kinesin-1 motor function.PloS one · 2022Article
- Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane.International journal of molecular sciences · 2021Review
- Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling.Frontiers in cell and developmental biology · 2021Review
- Mast cell desensitization inhibits calcium flux and aberrantly remodels actin.The Journal of clinical investigation · 2016Article
- Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- Cytoskeleton in mast cell signaling.Frontiers in immunology · 2012Article
- Article
- Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Depolymerisation and rearrangement of actin filaments during exocytosis in rat peritoneal mast cells: involvement of ryanodine-sensitive calcium stores.Pflugers Archiv : European journal of physiology · 2007Article
- Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.The Journal of cell biology · 2005Article
- Actin depolymerization transduces the strength of B-cell receptor stimulation.Molecular biology of the cell · 2005Article
- SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration.Molecular and cellular biology · 2004Article
- Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle.British journal of pharmacology · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. To determine the role of actin assembly in the Ca(2+) signalling of mast cells activated by cross-linking of FcepsilonRI, we examined the effects of cytochalasin D, an inhibitor of actin polymerization. 2. In the RBL-2H3 cells, F-actin content was increased by sensitization with anti-dinitrophenol (DNP) IgE. In these cells, cytochalasin D induced oscillatory increases in cytosolic Ca(2+) ([Ca(2+)](i)); these increase were inhibited by jasplakinolide, a stabilizer of actin filaments. 3. In the IgE-sensitized RBL-2H3 cells, DNP-human serum albumin (DNP-HSA) augmented actin assembly. DNP-HSA also increased the production of IP(3), [Ca(2+)](i) and degranulation. Cytochalasin D enhanced all of these DNP-HSA-induced effects. 4. In a Ca(2+)-free solution, DNP-HSA induced a transient increase in [Ca(2+)](i), and this increase was accelerated by cytochalasin D. After cessation of the DNP-HSA-induced Ca(2+) release, the re-addition of Ca(2+) induced a sustained increase in [Ca(2+)](i) through capacitative Ca(2+) entry (CCE), and this increase was enhanced by cytochalasin D. 5 The effect of cytochalasin D in enhancing the CCE activity was prevented by xestospongin C. 6. In contrast, neither the Ca(2+) release nor the CCE activation that was induced by thapsigargin was affected by cytochalasin D. 7. These results suggest that actin de-polymerization stimulates the FcepsilonRI-mediated signalling to augment the release of Ca(2+) from the endoplasmic reticulum in RBL-2H3 cells.
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