ArticleThe EMBO journal2002
Promoter competition as a mechanism of transcriptional interference mediated by retrotransposons.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Promoter strength and position govern promoter competition through transcript-dependent insulation.Nature genetics · 2026Article
- DNA regulatory element cooperation and competition in transcription.BMB reports · 2024Review
- Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions.Nature communications · 2023Article
- The Functional Meaning of 5'UTR in Protein-Coding Genes.International journal of molecular sciences · 2023Review
- The Structural, Functional and Evolutionary Impact of Transposable Elements in Eukaryotes.Genes · 2021Review
- Measuring and interpreting transposable element expression.Nature reviews. Genetics · 2020Review
- On the Population Dynamics of Junk: A Review on the Population Genomics of Transposable Elements.Genes · 2019Review
- Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse.BMC neuroscience · 2015Article
- A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly.PloS one · 2014Article
- Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function.Neuroscience · 2013Review
- Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics.PloS one · 2013Article
- Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control.Nucleic acids research · 2010Article
- Hose in Hose, an S locus-linked mutant of Primula vulgaris, is caused by an unstable mutation at the Globosa locus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Analysis of promoter activity in transgenic plants by normalizing expression with a reference gene: anomalies due to the influence of the test promoter on the reference promoter.Journal of biosciences · 2009Article
- Does selection against transcriptional interference shape retroelement-free regions in mammalian genomes?PloS one · 2008Article
- Article
- Transcriptional interference--a crash course.Trends in genetics : TIG · 2005Review
- Enhancer choice in cis and in trans in Drosophila melanogaster: role of the promoter.Genetics · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancers can function over great distances and interact with almost any kind of promoter, but insulators or promoter competition generally limit their effect to a single gene. We provide in vivo evidence that retroelements may establish promoter competition with their neighboring genes and restrict the range of action of an enhancer. We report that the retroelement Idefix from Drosophila melanogaster inhibits white gene expression in testes by a promoter competition mechanism that does not occur in the eyes. The sequence specificity of the two TATA-less promoters of white and Idefix is a prime determinant in the competition that takes place in tissues where both are transcriptionally active. This study brings to light a novel mechanism whereby transcriptional interference by an active retrotransposon may perturb expression of neighboring genes. This capacity to interfere with the transcriptional regulation of their host, together with the facts that retroelements preferentially move within the germline and do not excise to replicate, suggest that these elements are cis-regulatory sequences able to imprint specific and heritable controls essential for eukaryotic gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.