ArticleThe EMBO journal2002
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 123 citations in OpenAlex.
- High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults.BMC genomic data · 2025Article
- Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Learning cell identity in immunology, neuroscience, and cancer.Seminars in immunopathology · 2023Review
- Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.Nature communications · 2022Article
- Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi.Genome research · 2021Article
- Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.Experimental hematology · 2020Review
- To be red or white: lineage commitment and maintenance of the hematopoietic system by the "inner myeloid".Haematologica · 2019Review
- Understanding and Modulating Immunity With Cell Reprogramming.Frontiers in immunology · 2019Review
- High-throughput single-cell fate potential assay of murine hematopoietic progenitors in vitro.Experimental hematology · 2018Article
- Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.Nature immunology · 2018Article
- Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ.The Journal of comparative neurology · 2016Article
- PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness.Nature communications · 2016Article
- Asymmetric Regulation of Peripheral Genes by Two Transcriptional Regulatory Networks.PloS one · 2016Article
- Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis.Cell reports · 2015Article
- Transcription factor-mediated reprogramming toward hematopoietic stem cells.The EMBO journal · 2015Review
- Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.The Journal of clinical investigation · 2015Article
- Transcriptional network control of normal and leukaemic haematopoiesis.Experimental cell research · 2014Review
- Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells.Stem cell reports · 2014Article
- Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.Genes & development · 2014Article
- GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.Leukemia · 2014Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The developmental plasticity of transplanted adult stem cells challenges the notion that tissue-restricted stem cells have stringently limited lineage potential and prompts a re-evaluation of the stability of lineage commitment. Transformed cell systems are inappropriate for such studies, since transformation potentially dysregulates the processes governing lineage commitment. We have therefore assessed the stability of normal lineage commitment in primary adult haematopoietic cells. For these studies we have used prospectively isolated primary bipotent progenitors, which normally display only neutrophil and monocyte differentiation in vitro. In response to ectopic transcription factor expression, these neutrophil/monocyte progenitors were reprogrammed to take on erythroid, eosinophil and basophil-like cell fates, with the resultant colonies resembling the mixed lineage colonies normally generated by multipotential progenitors. Clone-marking and daughter cell experiments identified lineage switching rather than differential cell selection as the mechanism of altered lineage output. These results demonstrate that the cell type-specific programming of apparently committed primary progenitors is not irrevocably fixed, but may be radically re-specified in response to a single transcriptional regulator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.