ReviewArthritis research2002
Insights into integrin-ligand binding and activation from the first crystal structure.
Review in Arthritis research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Structural and mechanistic insights into α2β1 and α5β1 integrin targeting by bioengineered extracellular vesicles originating from lung cancer cells.Scientific reports · 2026Article
- Human Saposin B Ligand Binding and Presentation to α-Galactosidase A.bioRxiv : the preprint server for biology · 2024Article
- Integrins and their potential roles in mammalian pregnancy.Journal of animal science and biotechnology · 2023Review
- Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses.Research (Washington, D.C.) · 2023Article
- A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney.Molecular and cellular pediatrics · 2020Review
- Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype.Biomaterials · 2020Article
- PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.The Journal of clinical investigation · 2018Article
- Article
- Polydom/SVEP1 is a ligand for integrin α9β1.The Journal of biological chemistry · 2012Article
- Interaction of the α2A domain of integrin with small collagen fragments.Protein & cell · 2010Article
- The C-terminal region of laminin beta chains modulates the integrin binding affinities of laminins.The Journal of biological chemistry · 2009Article
- Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange.The Journal of physiology · 2005Article
- Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The alpha2beta1 integrin inhibitor rhodocetin binds to the A-domain of the integrin alpha2 subunit proximal to the collagen-binding site.The Biochemical journal · 2003Article
- Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.The EMBO journal · 2003Article
- Snail negatively regulates cell adhesion to extracellular matrix and integrin expression via the MAPK pathway in prostate cancer cells.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrin receptors transduce bidirectional signals between extracellular adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural basis of integrin signalling is unknown, but the recent publication of the first crystal structure of the extracellular domain of integrin alphaVbeta3 has provided a number of insights. In this review, previous structure-function analyses of integrins that have employed biochemical and molecular biological approaches are placed in the context of the crystal structure, and novel routes to the development of integrin antagonists are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.