ArticleClinical and experimental immunology2002
Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson's disease model.Communications biology · 2025Article
- MIF functional polymorphisms are associated with acute GVHD progression and steroid-refractoriness.Frontiers in immunology · 2025Article
- The distinct functions of MIF in inflammatory cardiomyopathy.Frontiers in immunology · 2025Review
- Associations of inflammatory cytokines with inflammatory bowel disease: a Mendelian randomization study.Frontiers in immunology · 2023Article
- Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis.BMC medical genetics · 2020Article
- Role of Host and Parasite MIF Cytokines duringTropical medicine and infectious disease · 2020Review
- IncreasedFrontiers in microbiology · 2019Article
- Enrofloxacin and Toltrazuril Are Able to ReduceFrontiers in cellular and infection microbiology · 2017Article
- Meta-analysis of macrophage migration inhibitory factor (MIF) gene -173G/C polymorphism and inflammatory bowel disease (IBD) risk.International journal of clinical and experimental medicine · 2015Article
- Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease.Annals of the New York Academy of Sciences · 2012Review
- Macrophage migration inhibitory factor gene -173G>C polymorphism and risk of bladder cancer in southeast China: a case-control analysis.Molecular biology reports · 2012Article
- Article
- Association between macrophage migration inhibitory factor promoter region polymorphism (-173 G/C) and cancer: a meta-analysis.BMC research notes · 2011Article
- DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis.Clinical and experimental immunology · 2011Article
- Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria.Nature reviews. Immunology · 2010Review
- Dendritic cells in intestinal homeostasis and disease.The Journal of clinical investigation · 2009Review
- The role of macrophage migration inhibitory factor on glucose metabolism and diabetes.Diabetologia · 2008Review
- Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Role of mucosal dendritic cells in inflammatory bowel disease.World journal of gastroenterology · 2008Review
- Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C.Clinical and experimental immunology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The level of macrophage migration inhibitory factor (MIF) and the functions of dendritic cells (DC) are up-regulated in the peripheral blood, and the numbers of MIF-expressing cells and mature DC are increased at the colonic mucosa from patients with ulcerative colitis (UC). However, a functional relationship between MIF and DC, and the role of MIF in the pathogenesis of UC, are not clear. In this study, we showed that a pure population of peripheral blood DC is a new and still unknown source of MIF. DC from UC patients produced significantly higher levels of MIF (17 x 5 +/- 9 x 8 ng/ml, n = 10) compared with patients with Crohns disease (CD) (4 x 6 +/- 2 x 5 ng/ml, n = 5, P< 0 x 01) and control subjects (5 x 0 +/- 2 x 6 ng/ml, n = 10, P< 0 x 01). A double immunofluorescence study revealed the expression of MIF by CD83-positive mature DC at the colonic mucosa from UC patients. Blood DC treated with high amounts of MIF (500 ng/ml) showed a significantly higher stimulatory capacity (43287 +/- 5998 CPM, n = 5) in an allogenic mixed leucocyte reaction compared with untreated DC (27528 +/- 8823 CPM, n = 5, P< 0 x 05). Study of intracellular cytokine expression showed that MIF induced significant levels of interleukin (IL)-1 and IL-8 in monocytes and DC from UC and CD patients. These results showing the capacity of MIF to induce increased functional capacity of DC, and to produce IL-1 and IL-8 from monocytes and DC, indicate a role of MIF in the induction and/or perpetuation of the inflammatory environment in UC.
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