ArticleThe American journal of pathology2002
Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Margin of Error: The Emerging Role of Field Cancerization in Predicting Recurrence Risk of Ductal Carcinoma In Situ.International journal of molecular sciences · 2026Review
- Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries.Breast cancer (Tokyo, Japan) · 2021Article
- Genetic Alterations in Benign Breast Biopsies of Subsequent Breast Cancer Patients.Frontiers in medicine · 2019Article
- HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell.Frontiers in microbiology · 2018Article
- Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma.Nature communications · 2017Article
- Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis.Journal of breast cancer · 2016Review
- Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer.Breast cancer : basic and clinical research · 2016Review
- Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Repeated anastomotic recurrence of colorectal tumors: genetic analysis of two cases.World journal of gastroenterology · 2011Article
- Gene expression profiles of estrogen receptor-positive and estrogen receptor-negative breast cancers are detectable in histologically normal breast epithelium.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.Oncotarget · 2010Review
- Concordance of metabolic enzyme genotypes assayed from paraffin-embedded, formalin-fixed breast tumors and normal lymphatic tissue.Clinical epidemiology · 2010Article
- Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids.International journal of cancer · 2010Article
- Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.Breast cancer research and treatment · 2010Article
- SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue.Oncogene · 2009Article
- Clinical implications and utility of field cancerization.Cancer cell international · 2007Article
- p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.PLoS biology · 2006Article
- Gene expression signatures of morphologically normal breast tissue identify basal-like tumors.Breast cancer research : BCR · 2006Article
- Do myoepithelial cells hold the key for breast tumor progression?Journal of mammary gland biology and neoplasia · 2005Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To better understand early steps in human breast carcinogenesis, we examined allele imbalance or loss of heterozygosity (LOH), in co-existing normal-appearing breast epithelium and cancers. We microdissected a total of 173 histologically normal ducts or terminal ductolobular units (TDLUs) and malignant epithelial samples from 18 breast cancer cases, and examined their DNA for LOH at 21 microsatellite markers on 10 chromosome arms. Fourteen of 109 (13%) normal ducts/TDLUs, from 8 of 18 (44%) cases, contained LOH. The location of these 14 ducts/TDLUs appeared unrelated to distance from the cancer. LOH in normal-appearing epithelium involved only single markers, whereas LOH in cancers commonly encompassed all informative markers on a chromosome arm. In only 1 of 14 (7%) ducts/TDLUs with LOH, was the same LOH seen in the co-existing cancer. Global differences in LOH per arm in normal-appearing tissue were not demonstrated, but less LOH was seen at 11q and 17p than at 1q (P = 0.002), 16q (P = 0.01), and possibly 17q (P = 0.06). These results indicate that in a large fraction of women with breast cancer, histologically normal breast epithelium harbors occult aberrant clones. Individual clones rarely are precursors of co-existing cancers. However, they might constitute a reservoir from which proliferative lesions or second cancers develop once additional genetic abnormalities occur, they could contribute to intratumoral genetic heterogeneity, and they are consistent with a role for genetic instability early in tumorigenesis.
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Registered trials
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