ArticleThe American journal of pathology2002
Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 105 citations in OpenAlex.
- Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously afterWorld journal of gastrointestinal oncology · 2024Article
- Should All Patients With Stage IE Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Receive Antibiotic Eradication Therapy forJCO oncology practice · 2024Article
- Gastric Mucosa-associated Lymphoid Tissue Lymphoma That Relapsed after 11 Years Subsequent to Achieving Complete Remission.Internal medicine (Tokyo, Japan) · 2024Article
- A case of a pulmonary mucosa-associated lymphoid tissue lymphoma with chromosomal aberration (49, XX, +3, +i(6)(p10), +mar).Respirology case reports · 2019Article
- Two cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma masquerading as follicular gastritis.Ecancermedicalscience · 2019Article
- The Diagnosis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma by Flow Cytometry and Fluorescence in situ Hybridization of Biopsy Specimens.Internal medicine (Tokyo, Japan) · 2018Article
- Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma.Journal of hematopathology · 2017Review
- Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theWorld journal of gastroenterology · 2017Article
- Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type.Clinical journal of gastroenterology · 2013Article
- Ocular adnexal non-Hodgkin's lymphoma: a review of epidemiology and risk factors.Expert review of ophthalmology · 2011Article
- t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.Journal of cancer research and clinical oncology · 2010Article
- Chlamydial infection: the link with ocular adnexal lymphomas.Nature reviews. Clinical oncology · 2009Review
- Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma.Cancer science · 2009Article
- Article
- Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists.Journal of clinical pathology · 2007Review
- Article
- Current status of gastric MALT lymphoma.Current gastroenterology reports · 2006Review
- Overlapping morphologic and immunophenotypic profiles in small B-cell lymphoma. A report of two cases.Virchows Archiv : an international journal of pathology · 2006Article
- T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.Leukemia · 2005Article
- 18q21 Rearrangement and trisomy 3 in extranodal B-cell lymphomas: a study using a fluorescent in situ hybridisation technique.Virchows Archiv : an international journal of pathology · 2004Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their relationship and clinical significance, we developed a two-color fluorescence in situ hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all previously evaluated for t(11;18) by reverse transcriptase-polymerase chain reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 16 controls were tested by FISH using the t(11;18) probe set and multiple centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (n = 12), 3 (n = 8), 7 (n = 2), and/or 11 (n = 1). t(11;18) and aneuploidy are primarily mutually exclusive events, suggesting different pathogenetic pathways in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen disproportionately in lung, and both were associated with recurrent disease.
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