ReviewArthritis research2002
The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases.
Review in Arthritis research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.Journal of immunotherapy (Hagerstown, Md. : 1997)Trial
- CD8Rheumatology and immunology research · 2021Review
- Cellular and Molecular Phenotypes of pConsensus Peptide (pCons) Induced CD8Frontiers in immunology · 2021Article
- Crosstalk between T Helper Cell Subsets and Their Roles in Immunopathogenesis and Outcome of Polytrauma Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity.Biomolecules · 2019Review
- Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells.Cells · 2019Review
- A protocol for humanized synovitis mice model.American journal of clinical and experimental immunology · 2019Article
- Occupational exposure to formaldehyde and alterations in lymphocyte subsets.American journal of industrial medicine · 2013Article
- Regulatory T cells and Atherosclerosis.Journal of clinical & experimental cardiology · 2012Article
- Genes, tolerance and systemic autoimmunity.Autoimmunity reviews · 2012Review
- Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.PLoS biology · 2010Article
- Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway.BMC immunology · 2009Article
- Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation.Atherosclerosis · 2009Article
- Higher expression of Bax in regulatory T cells increases vascular inflammation.Frontiers in bioscience : a journal and virtual library · 2008Article
- Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Regulatory T cells in renal disease.International journal of clinical and experimental medicine · 2008Article
- Article
- VASCULAR INFLAMMATION AND ATHEROGENESIS ARE ACTIVATED VIA RECEPTORS FOR PAMPs AND SUPPRESSED BY REGULATORY T CELLS.Drug discovery today. Therapeutic strategies · 2008Article
- Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.The Journal of experimental medicine · 2006Article
- TH2 cells in the pathogenesis of airway remodeling: regulatory T cells a plausible panacea for asthma.Immunologic research · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional' suppressor cells and other cytokine-producing CD4+ and CD8+ T-cell subsets mediate this protective function. Evidence will be reviewed that T cells primed with transforming growth factor (TGF)-beta expand rapidly following restimulation. Certain CD4+ T cells become contact-dependent suppressor cells and other CD4+ and CD8+ cells become cytokine-producing regulatory cells. This effect is dependent upon a sufficient amount of IL-2 in the microenvironment to overcome the suppressive effects of TGF-beta. The adoptive transfer of these suppressor cells generated ex vivo can protect mice from developing chronic graft-versus-host disease with a lupus-like syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-beta have the potential to be used as a therapy for patients with systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.