ArticleOncogene2002
Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling.Oncogene · 2007Trial
- Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum-A Case Report and Brief Review of the Literature.Reports (MDPI) · 2024Article
- Iron metabolism in colorectal cancer: a balancing act.Cellular oncology (Dordrecht, Netherlands) · 2023Review
- Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer.Cancer immunology research · 2023Article
- Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer.Frontiers in oncology · 2022Article
- Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumorsTurkish journal of medical sciences · 2021Article
- Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape.Frontiers in oncology · 2021Article
- 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.Chemical research in toxicology · 2018Article
- High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer.American journal of cancer research · 2018Article
- Article
- Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens.Clinical epigenetics · 2017Article
- MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties.Journal of cellular and molecular medicine · 2017Article
- Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.Gastroenterology · 2016Article
- The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair.Nucleic acids research · 2016Article
- Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples.Diagnostic pathology · 2015Article
- Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis.Oncotarget · 2015Article
- Article
- Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.Cancer biology & therapy · 2014Article
- Intestinal iron homeostasis and colon tumorigenesis.Nutrients · 2013Review
- Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.Oncogene · 2013Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
In order to discover global gene expression patterns characterizing subgroups of colon cancer, microarrays were hybridized to labeled RNAs obtained from seventeen colonic specimens (nine carcinomas and eight normal samples). Using a hierarchical agglomerative method, the samples grouped naturally into two major clusters, in perfect concordance with pathological reports (colon cancer versus normal colon). Using a variant of the unpaired t-test, selected genes were ordered according to an index of importance. In order to confirm microarray data, we performed quantitative, real-time reverse transcriptase-polymerase chain reaction (TaqMan RT-PCR) on RNAs from 13 colorectal tumors and 13 normal tissues (seven of which were matched normal-tumor pairs). RT-PCR was performed on the gro1, B-factor, adlican, and endothelin converting enzyme-1 genes and confirmed microarray findings. Two hundred and fifty genes were identified, some of which were previously reported as being involved in colon cancer. We conclude that cDNA microarraying, combined with bioinformatics tools, can accurately classify colon specimens according to current histopathological taxonomy. Moreover, this technology holds promise of providing invaluable insight into specific gene roles in the development and progression of colon cancer. Our data suggests that a large-scale approach may be undertaken with the purpose of identifying biomarkers relevant to cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.