ArticleOncogene2002
p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 124 citations in OpenAlex.
- High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia.Blood · 2015Trial
- Review
- The p53 family member p73 in the regulation of cell stress response.Biology direct · 2021Review
- Review
- Epigenetic modification in the expression of p73 p73 - epigenetic target for anticancer therapy.Oncology reviews · 2019Article
- The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells.Scientific reports · 2017Article
- RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense.The Journal of biological chemistry · 2016Article
- ∆Np73 is capable of inducing apoptosis by co-ordinately activating several BH3-only proteins.Bioscience reports · 2015Article
- Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.Oncotarget · 2014Article
- TAp73 and ΔNp73 have opposing roles in 5-aza-2'-deoxycytidine-induced apoptosis in breast cancer cells.Molecules and cells · 2014Article
- The transcription factor p53: not a repressor, solely an activator.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.The Journal of biological chemistry · 2013Article
- Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.PLoS pathogens · 2013Article
- Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity.Cell death and differentiation · 2012Article
- Article
- P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.Oncogene · 2011Article
- p73 as a pharmaceutical target for cancer therapy.Current pharmaceutical design · 2011Review
- Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.Oncogene · 2010Article
- Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53 tumor suppressor protein activates transcription and induces cell death. A close homologue of p53, termed p73, is expressed in transactivating (TA) forms that induce growth arrest and apoptosis much like p53. However, the p73 gene contains a second promoter, giving rise to the expression of p73 Delta N, a species of p73 proteins that lack the N-terminal transactivation domain. We show here that the expression of p73 Delta N is induced by p53 on the mRNA and protein level. The promoter that regulates p73 Delta N expression in human cells was cloned and found to be activated by p53, as well as by p73TA, directly through a specific DNA element. The p73 Delta N proteins, that are thereby expressed, bound to p53-responsive promoter DNA, competed with p53 for DNA binding, antagonized the activation of transcription by p53, and prevented p53-induced cell death. In addition, a transcriptional repressor domain was identified within the splicing variant p73 Delta Nalpha. The combination of p73DeltaNalpha and mdm2 antagonized p53 more strongly than either p73Nalpha or mdm2 alone. Blocking endogenous p73 Delta N by a trans dominant fragment, or its removal by siRNA, increased the activity of a p53-responsive promoter in cells that contain a wild type p53 gene. Thus, the induction of p73 Delta N expression by p53 establishes an autoregulatory feedback loop that keeps the trigger of cell death under tight control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.