ArticleJournal of leukocyte biology2002
Rate and extent of phagocytosis in macrophages lacking vamp3.
Article in Journal of leukocyte biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- VAMP3 and VAMP8 Regulate the Development and Functionality of Parasitophorous Vacuoles Housing Leishmania amazonensis.Infection and immunity · 2022Article
- Multifunctional regulation of VAMP3 in exocytic and endocytic pathways of RBL-2H3 cells.Frontiers in immunology · 2022Article
- PKC-ε regulates vesicle delivery and focal exocytosis for efficient IgG-mediated phagocytosis.Journal of cell science · 2021Article
- LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer.Aging · 2020Article
- Article
- Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE.The Journal of biological chemistry · 2016Article
- Blocking the expression of syntaxin 4 interferes with initial phagocytosis of Brucella melitensis in macrophages.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2015Article
- PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.Journal of leukocyte biology · 2013Article
- Silencing of VAMP3 expression does not affect Brucella melitensis infection in mouse macrophages.Virulence · 2012Article
- A novel function for SNAP29 (synaptosomal-associated protein of 29 kDa) in mast cell phagocytosis.PloS one · 2012Article
- Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.Molecular biology of the cell · 2007Article
- Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages.The EMBO journal · 2004Article
- Identification and subcellular localization of neuronal calcium sensor-1 (NCS-1) in human neutrophils and HL-60 cells.Inflammation · 2003Article
- ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages.The Journal of cell biology · 2003Article
- Phagosome maturation: a few bugs in the system.The Journal of membrane biology · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
During phagocytosis, macrophages rapidly internalize a substantial fraction of plasma membrane without a net loss of surface area, suggesting that membranes are targeted to the cell surface from intracellular sites. Nevertheless, a requirement for mobilization of specific membrane compartments has not been demonstrated. We used bone marrow-derived macrophages (BMM) from wild type and vamp3 null mice to evaluate directly the requirement for this v-SNARE in phagocytosis of zymosan, IgG-beads, complement-opsonized particles, or latex microspheres. Regardless of the phagocytic receptor engaged or particle load, BMM lacking vamp3 exhibited no phagocytic defects when assayed after 1 h at 37 degrees C, and phagosome maturation was unimpaired as judged by acquisition of lamp-1. In contrast, at early time points (5-15 min), internalization of zymosan (but not other particles tested) was significantly slower in vamp3 null BMM. These data indicate that vamp3 modulates efficient uptake of zymosan, but is not absolutely required for phagocytosis in primary macrophages.
Indexed as
Identifiers
12101283PMC1828116W2119466361What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.