ArticleMolecular and cellular biology2002
E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 112 citations in OpenAlex.
- pRb2/p130 protein in relation to clinicopathological and biological variables in rectal cancers with a clinical trial of preoperative radiotherapy.International journal of colorectal disease · 2009Trial
- Article
- Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells.Environmental toxicology · 2021Article
- E2F1-directed activation of nc886 mediates drug resistance in cervical cancer cells via regulation of major vault protein.International journal of clinical and experimental pathology · 2017Article
- Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885.Nutrients · 2014Article
- The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis.The Journal of biological chemistry · 2013Article
- Conserved RB functions in development and tumor suppression.Protein & cell · 2011Review
- Targeting Rb inactivation in cancers by synthetic lethality.American journal of cancer research · 2011Article
- Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Future oncology (London, England) · 2010Review
- Functional interplay between E2F1 and chemotherapeutic drugs defines immediate E2F1 target genes crucial for cancer cell death.Cellular and molecular life sciences : CMLS · 2010Article
- p53 and E2f: partners in life and death.Nature reviews. Cancer · 2009Review
- Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.The American journal of pathology · 2009Article
- Balancing the decision of cell proliferation and cell fate.Cell cycle (Georgetown, Tex.) · 2009Review
- E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.PLoS genetics · 2008Article
- Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.Developmental cell · 2008Article
- An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.Cancer cell · 2008Article
- Life and death decisions by the E2F transcription factors.Current opinion in cell biology · 2007Review
- Proapoptotic role of novel gene-expression factors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2007Review
- E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma.Oncogene · 2007Article
- Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology.Neurobiology of disease · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
It has been proposed that the E2F1 transcription factor serves as a link between the Rb/E2F proliferation pathway and the p53 apoptosis pathway by inducing the expression of p19ARF, a protein that regulates p53 stability. We find that although p19ARF contributes to p53 accumulation in response to E2F expression, p19ARF is not required for E2F1-mediated apoptosis. E2F1 can signal p53 phosphorylation in the absence of p19ARF, similar to the observed modifications to p53 in response to DNA damage. These modifications are not observed in the absence of p19ARF following expression of E2F2, an E2F family member that does not induce apoptosis in mouse embryo fibroblasts but can induce p19ARF and p53 protein expression. p53 modification is found to be crucial for E2F1-mediated apoptosis, and this apoptosis is compromised when E2F1 is coexpressed with a p53 mutant lacking many N- and C-terminal phosphorylation sites. Additionally, E2F1-mediated apoptosis is abolished in the presence of caffeine, an inhibitor of phosphatidylinositol 3-kinase-related kinases that phosphorylate p53. These findings suggest that p53 phosphorylation is a key step in E2F1-mediated apoptosis and that this modification can occur in the absence of p19ARF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.