ArticleGenes & development2002
Spo13 regulates cohesin cleavage.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Rewiring of the phosphoproteome executes two meiotic divisions in budding yeast.The EMBO journal · 2024Article
- Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation.Frontiers in cell and developmental biology · 2021Review
- Spo13 prevents premature cohesin cleavage during meiosis.Wellcome open research · 2019Article
- The cohesin complex in mammalian meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2019Review
- An interplay between Shugoshin and Spo13 for centromeric cohesin protection and sister kinetochore mono-orientation during meiosis I in Saccharomyces cerevisiae.Current genetics · 2018Article
- Article
- A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.PLoS biology · 2013Article
- Co-segregation of yeast plasmid sisters under monopolin-directed mitosis suggests association of plasmid sisters with sister chromatids.Nucleic acids research · 2013Article
- Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.Genetics · 2010Article
- Mechanism of haploidy-dependent unreductional meiotic cell division in polyploid wheat.Chromosoma · 2010Article
- Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation.Genes & development · 2008Article
- Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae.Genetics · 2007Article
- Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
- The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I.Genes & development · 2005Article
- Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Article
- Rephrasing anaphase: separase FEARs shugoshin.Chromosoma · 2005Review
- Loss of meiotic rereplication block in Saccharomyces cerevisiae cells defective in Cdc28p regulation.Eukaryotic cell · 2005Article
- The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II.Current genetics · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A key aspect of meiotic chromosome segregation is that cohesin, the protein complex that holds sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric regions during meiosis II. The budding yeast protein Spo13 plays a key role in preventing centromeric cohesin from being lost during meiosis I. We have determined the molecular basis for the metaphase arrest obtained when SPO13 is overexpressed during the mitotic cell cycle. Overexpression of SPO13 inhibits anaphase onset by at least two mechanisms. First, Spo13 causes a transient delay in degradation of the anaphase inhibitor Pds1. Second, Spo13 inhibits cleavage of the cohesin subunit Scc1/Mcd1 or its meiosis-specific homolog, Rec8, by the separase Esp1. The finding that Spo13 did not prevent cleavage of another Esp1 substrate, Slk19, suggests that overexpression of SPO13 is sufficient to prevent cohesin cleavage by protecting specific substrates from separase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.