ArticleEMBO reports2002
Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Toll signalling controls intestinal regeneration in Drosophila.Development (Cambridge, England) · 2026Article
- Chromosome-Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Innate Immune Response ofInternational journal of molecular sciences · 2023Article
- Article
- Review
- Review
- Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors.Journal of biomedical science · 2019Review
- Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression inThe Journal of biological chemistry · 2019Article
- TmToll-7 Plays a Crucial Role in Innate Immune Responses Against Gram-Negative Bacteria by Regulating 5 AMP Genes inFrontiers in immunology · 2019Article
- Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.Developmental cell · 2018Article
- RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides.PLoS pathogens · 2018Article
- De Novo Assembly and Characterization of the Xenocatantops brachycerus Transcriptome.International journal of molecular sciences · 2018Article
- The Fly Way of Antiviral Resistance and Disease Tolerance.Advances in immunology · 2018Review
- Article
- A novel mode of induction of the humoral innate immune response inDisease models & mechanisms · 2017Article
- Activation of Toll Pathway Is Different between Kuruma Shrimp andFrontiers in immunology · 2017Article
- Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity.Journal of virology · 2016Article
- Differential gene expression and alternative splicing in insect immune specificity.BMC genomics · 2014Article
- Conventional and non-conventional Drosophila Toll signaling.Developmental and comparative immunology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Essential aspects of innate immune responses to microbial infections appear to be conserved between insects and mammals. In particular, in both groups, transmembrane receptors of the Toll superfamily play a crucial role in activating immune defenses. The Drosophila Toll family member 18-Wheeler had been proposed to sense Gram-negative infection and direct selective expression of peptides active against Gram-negative bacteria. Here we re-examine the role of 18-Wheeler and show that in adults it is dispensable for immune responses. In larvae, 18wheeler is required for normal fat body development, and in mutant larvae induction of all antimicrobial peptide genes, and not only of those directed against Gram-negative bacteria, is compromised. 18-Wheeler does not qualify as a pattern recognition receptor of Gram-negative bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.