ArticleEMBO reports2002
Intranuclear degradation of nonsense codon-containing mRNA.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Real-time imaging of transcriptional feedback in nonsense-mediated mRNA decay.Science advances · 2026Article
- The nuclear cap-binding complex regulates subcellular RNA processing and surveillance of coding and noncoding RNAs.Nucleic acids research · 2026Article
- Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression inInternational journal of molecular sciences · 2022Article
- Control of gene expression through the nonsense-mediated RNA decay pathway.Cell & bioscience · 2017Review
- NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events.PloS one · 2017Article
- Article
- Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.Molecular medicine reports · 2016Article
- Temporal and spatial characterization of nonsense-mediated mRNA decay.Genes & development · 2013Article
- When a ribosome encounters a premature termination codon.BMB reports · 2013Review
- Organizing principles of mammalian nonsense-mediated mRNA decay.Annual review of genetics · 2013Review
- Cotranscriptional effect of a premature termination codon revealed by live-cell imaging.RNA (New York, N.Y.) · 2011Article
- The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Molecular cell · 2009Article
- Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus.The Plant cell · 2009Article
- Nonsense codons trigger an RNA partitioning shift.The Journal of biological chemistry · 2009Article
- Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation.Matrix biology : journal of the International Society for Matrix Biology · 2008Article
- Association of ribosomal proteins with nascent transcripts in S. cerevisiae.RNA (New York, N.Y.) · 2005Article
- Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence.RNA (New York, N.Y.) · 2005Article
- Premature termination codons do not affect the rate of splicing of neighboring introns.RNA (New York, N.Y.) · 2004Article
- Cytoplasmic foci are sites of mRNA decay in human cells.The Journal of cell biology · 2004Article
- An unappreciated role for RNA surveillance.Genome biology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most vertebrate mRNAs with premature termination codons (PTCs) are specifically recognized and degraded by a process referred to as nonsense-mediated mRNA decay (NMD) while still associated with the nucleus. However, it is still a matter of debate whether PTCs can be identified by intranuclear scanning or only by ribosomes on the cytoplasmic side of the nuclear envelope. Here we show that inhibition of mRNA export by two independent approaches does not affect the downregulation of PTC-containing T-cell receptor beta transcripts in the nuclear fraction of mammalian cells, providing strong evidence for intranuclear NMD. Our results are fully consistent with recently reported evidence for nuclear translation and suggest that an important biological role for nuclear ribosomes is the early elimination of nonsense mRNA during a pioneer round of translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.