ArticleJournal of assisted reproduction and genetics2002
The human ASCL2 gene escaping genomic imprinting and its expression pattern.
Article in Journal of assisted reproduction and genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells.bioRxiv : the preprint server for biology · 2025Article
- The structure of the TH/INS locus and the parental allele expressed are not conserved between mammals.Heredity · 2024Article
- Modeling human epigenetic disorders in mice: Beckwith-Wiedemann syndrome and Silver-Russell syndrome.Disease models & mechanisms · 2020Review
- Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.Disease models & mechanisms · 2018Article
- Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome.Development (Cambridge, England) · 2017Article
- Signaling pathways in mouse and human trophoblast differentiation: a comparative review.Cellular and molecular life sciences : CMLS · 2015Review
- The placental imprintome and imprinted gene function in the trophoblast glycogen cell lineage.Reproductive biomedicine online · 2012Review
- Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells.Development (Cambridge, England) · 2011Article
- Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.Developmental biology · 2011Article
- The importance of imprinting in the human placenta.PLoS genetics · 2010Review
- Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome.BMC developmental biology · 2010Article
- Characterization of conserved and nonconserved imprinted genes in swine.Biology of reproduction · 2009Article
- Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.Oncogene · 2006Article
- JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2).Molecular and cellular biology · 2005Article
- Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region.Genome research · 2005Article
- Evolution of the Beckwith-Wiedemann syndrome region in vertebrates.Genome research · 2005Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.