ArticleJournal of assisted reproduction and genetics2002
Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia.
Article in Journal of assisted reproduction and genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Polymorphisms within the Tumor Necrosis Factor-Alpha Gene Is Associated with Preeclampsia in Taiwanese Han Populations.Biomedicines · 2023Article
- Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics.Ageing research reviews · 2022Review
- Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review.Current hypertension reports · 2018Review
- Tumor necrosis factor-alpha polymorphism at position -238 in preeclampsia.Iranian Red Crescent medical journal · 2014Article
- Lack of association between TNF-α gene polymorphisms at position -308 A, -850T and risk of simple febrile convulsion in pediatric patients.Advanced biomedical research · 2012Article
- Recent insights into the pathophysiology of preeclampsia.Expert review of obstetrics & gynecology · 2010Article
- Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium.Placenta · 2009Review
- The association between polymorphism of TNF-alpha gene and hypertensive disorder complicating pregnancy.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe determined whether genetic variability in the gene encoding for tumor necrosis factor-alpha (TNF-alpha) contributes to individual differences in susceptibility to the development of preeclampsia.
methodsThe study involved 133 preeclamptic and 115 healthy control pregnant women who were genotyped for C-850T polymorphism in the TNF-alpha gene promoter. Chi-square analysis was used to assess genotype and allele frequency differences between preeclamptic women and controls.
resultsA significantly different genotype distribution of C-850T polymorphism was observed between the two groups, with the frequency of the variant T allele being significantly reduced in the preeclamptic group (4.5%) when compared with the control group (9.6%) (P = 0.03; OR = 0.45, 95% CI = 0.22-0.92). Accordingly, the odds ratio for preeclampsia associated with the pooled TT and CT genotypes was 0.367 (P = 0.02; 95% CI = 0.159-0.847).
conclusionsThe T allele of the TNF-alpha gene may modify individual preeclampsia risk, being protective against the development of the complication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.