ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.Cell reports · 2024Article
- Cell-Type-Specific Effects of Somatostatin on Synaptic Transmission in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.Frontiers in physiology · 2024Review
- Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022Review
- Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System.International journal of molecular sciences · 2021Review
- Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala.Neuroscience · 2019Article
- The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.Molecular brain · 2016Article
- Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons.Scientific reports · 2016Article
- Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits.Frontiers in neural circuits · 2016Review
- Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus.Neuropharmacology · 2015Article
- G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.Molecular pain · 2015Article
- Contribution of parvalbumin and somatostatin-expressing GABAergic neurons to slow oscillations and the balance in beta-gamma oscillations across cortical layers.Frontiers in neural circuits · 2015Article
- Article
- Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.Genes, brain, and behavior · 2012Article
- Attenuation of inhibitory synaptic transmission by glial dysfunction in rat thalamus.Synapse (New York, N.Y.) · 2011Article
- Frequency-dependent release of substance P mediates heterosynaptic potentiation of glutamatergic synaptic responses in the rat visual thalamus.Journal of neurophysiology · 2010Article
- Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Nature reviews. Neuroscience · 2010Review
- Excitatory actions of peptide histidine isoleucine on thalamic relay neurons.Neuropharmacology · 2008Article
- Presynaptic modulation by somatostatin in the neostriatum.Neurochemical research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the effects of somatostatin (SST) on neurons in the thalamic reticular nucleus (RT) using whole-cell patch-clamp techniques applied to visualized neurons in rat thalamic slices. SST, acting via sst(5) receptors and pertussis toxin-sensitive G-proteins, activated an inwardly rectifying K(+) (GIRK) current in 20 of 28 recorded cells to increase input conductance 15 +/- 3% above control and inhibited N-type Ca(2+) currents in 17 of 24 neurons via voltage-dependent mechanisms. SST reversibly depressed evoked EPSCs (eEPSCs) to 37 +/- 8% of control without altering their kinetics. SST-mediated inhibition of eEPSCs showed short-term relief from block during 25 Hz stimulus trains. SST also reduced the frequency (33 +/- 8%) but not the amplitude of miniature EPSCs (mEPSCs). These data indicate that SST mediates presynaptic inhibition of glutamate release onto RT neurons. In current-clamp recordings, SST preferentially inhibited burst discharges mediated by near-threshold corticothalamic EPSPs and intracellularly applied depolarizing currents. SST had powerful effects on in vitro intrathalamic rhythms, which included a shortening of the duration and a reduction in spike count within each oscillatory event. Furthermore, there was a paradoxical increase in the synchrony of epileptiform oscillations, likely mediated by a suppression of the responses to weak synaptic inputs in RT. We conclude that SST suppresses discharges in RT neurons, via presynaptic inhibition of glutamate release and postsynaptic activation of GIRK channels, leading to the dampening of both spindle-like and epileptiform thalamic network oscillations. SST may act as an important endogenous regulator of physiological and pathological thalamocortical network activities.
Indexed as
Identifiers
12097489PMC6758225W2169221312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.