ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Structural and molecular differentiation of cultured human neurons is accompanied by alterations of spontaneous and evoked calcium dynamics.Scientific reports · 2025Article
- Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium.International journal of molecular sciences · 2020Review
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- Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.Molecular neurobiology · 2019Article
- Assembly of fibronectin fibrils selectively attenuates platelet-derived growth factor-induced intracellular calcium release in fibroblasts.The Journal of biological chemistry · 2018Article
- Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.American journal of physiology. Endocrinology and metabolism · 2014Article
- Molecular and functional identification of a mitochondrial ryanodine receptor in neurons.Neuroscience letters · 2014Article
- The role of chromogranin B in an animal model of multiple sclerosis.Molecular and cellular neurosciences · 2013Article
- Prevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- C-terminal domain of chromogranin B regulates intracellular calcium signaling.The Journal of biological chemistry · 2011Article
- Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.The journal of physiological sciences : JPS · 2011Article
- The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves.Neuro-Signals · 2011Article
- Article
- Inositol 1,4,5-trisphosphate receptor in chromaffin secretory granules and its relation to chromogranins.Cellular and molecular neurobiology · 2010Review
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes.Circulation research · 2008Article
- Inositol 1,4,5-trisphosphate receptor movement is restricted by addition of elevated levels of O-linked sugar.Cell calcium · 2008Article
- Regulation of the inositol 1,4,5-trisphosphate receptor type I by O-GlcNAc glycosylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus.Journal of neuroscience research · 2007Article
- Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Intracellular calcium signals have distinct temporal and spatial patterns in neurons in which signal initiation and repetitive spiking occurs predominantly in the neurite. We investigated the functional implications of the coexpression of different isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using immunocytochemistry, Western blotting, and calcium imaging in neuronally differentiated PC12 cells. InsP3R type III, an isoform that has been shown to be upregulated in neuronal apoptosis, is exclusively expressed in the soma, serving as a gatekeeper for high-magnitude calcium surges. InsP3R type I is expressed throughout the cell and can be related to signal initiation and repetitive spiking in the neurite. RyR types 2 and 3 are distributed throughout the cell. In the soma, they serve as amplifying molecular switches, facilitating recruitment of the InsP3R type III-dependent pool. In the neurite, they decrease the probability of repetitive spiking. Use of a cell-permeant analog of InsP3 suggested that regional specificity in InsP3 production and surface-to-volume effects play minor roles in determining temporal and spatial calcium signaling patterns in neurons. Our findings suggest that additional modulatory processes acting on the intracellular channels are necessary to generate spatially specific calcium signaling.
Indexed as
Identifiers
12097486PMC6758205W2111402158What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.