ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Absence of long-term depression in the visual cortex of glutamic Acid decarboxylase-65 knock-out mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed.
- Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush.International journal of molecular sciences · 2021Article
- Postpartum State, but Not Maternal Caregiving or Level of Anxiety, Increases Medial Prefrontal Cortex GADFrontiers in global women's health · 2021Article
- Molecular Basis of GABA Hypofunction in Adolescent Schizophrenia-Like Animals.Neural plasticity · 2021Article
- Synaptic and circuit development of the primary sensory cortex.Experimental & molecular medicine · 2018Review
- Arc restores juvenile plasticity in adult mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.PloS one · 2016Article
- Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Visual experience prevents dysregulation of GABAB receptor-dependent short-term depression in adult superior colliculus.Journal of neurophysiology · 2015Article
- The glutamine-glutamate/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism.Neurochemical research · 2015Review
- Lower glutamic acid decarboxylase 65-kDa isoform messenger RNA and protein levels in the prefrontal cortex in schizoaffective disorder but not schizophrenia.Biological psychiatry · 2015Article
- A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity.Neuron · 2013Article
- Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Sublinear binocular integration preserves orientation selectivity in mouse visual cortex.Nature communications · 2013Article
- Reduced glutamate decarboxylase 65 protein within primary auditory cortex inhibitory boutons in schizophrenia.Biological psychiatry · 2012Article
- Dark exposure extends the integration window for spike-timing-dependent plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Perisomatic inhibition and cortical circuit dysfunction in schizophrenia.Current opinion in neurobiology · 2011Review
- Differential distribution of proteins regulating GABA synthesis and reuptake in axon boutons of subpopulations of cortical interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Developmental switch in the polarity of experience-dependent synaptic changes in layer 6 of mouse visual cortex.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Long-term depression (LTD) is widely considered a mechanism for experience-induced synaptic weakening in the brain. Recent in vivo studies on glutamic acid decarboxylase [GAD 65 (-/-)] knock-out mice indicates that GABAergic synaptic inhibition is also required for the normal weakening of deprived inputs in the visual cortex. To better understand how GABAergic inhibition might control plasticity, we assessed the status of synaptic inhibition and LTD in visual cortical slices of GAD 65 knock-out mice. We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice. These results suggest that a certain inhibitory tone is required for the induction of LTD in visual cortex. We propose that the lack of visual cortical LTD in GAD 65 (-/-) may account for the lack of experience-dependent plasticity in these mice.
Indexed as
Identifiers
12097476PMC6758224What OpenQuestion holds
Registered trials
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