ArticleGenome research2002
High-throughput gene mapping in Caenorhabditis elegans.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Genomic sequence and structural variations accumulating between laboratory lineages of wild typebioRxiv : the preprint server for biology · 2026Article
- Transposable elements and heterochromatic regions are enriched for structural variation and sequence divergence in the genome of wild-type Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes.Genome biology · 2024Article
- Comprehensive detection of structural variation and transposable element differences between wild type laboratory lineages ofbioRxiv : the preprint server for biology · 2023Article
- MJL-1 is a nuclear envelope protein required for homologous chromosome pairing and regulation of synapsis during meiosis inScience advances · 2023Article
- Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection.BMC genomics · 2022Article
- The intrinsically disordered protein SPE-18 promotes localized assembly of MSP inDevelopment (Cambridge, England) · 2021Article
- A Novel Gene Underlies Bleomycin-Response Variation inGenetics · 2019Article
- Recompleting theGenome research · 2019Article
- Article
- Reliable Biomarker discovery from Metagenomic data via RegLRSD algorithm.BMC bioinformatics · 2017Article
- Consistent metagenomic biomarker detection via robust PCA.Biology direct · 2017Article
- Evaluating alignment and variant-calling software for mutation identification in C. elegans by whole-genome sequencing.PloS one · 2017Article
- A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans.Development (Cambridge, England) · 2016Article
- Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans.PLoS genetics · 2016Article
- Mapping Challenging Mutations by Whole-Genome Sequencing.G3 (Bethesda, Md.) · 2016Article
- Genome-wide polymorphism and signatures of selection in the symbiotic sea anemone Aiptasia.BMC genomics · 2016Article
- Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856.Genetics · 2015Article
- Article
- A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.Genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Positional cloning of mutations in model genetic systems is a powerful method for the identification of targets of medical and agricultural importance. To facilitate the high-throughput mapping of mutations in Caenorhabditis elegans, we have identified a further 9602 putative new single nucleotide polymorphisms (SNPs) between two C. elegans strains, Bristol N2 and the Hawaiian mapping strain CB4856, by sequencing inserts from a CB4856 genomic DNA library and using an informatics pipeline to compare sequences with the canonical N2 genomic sequence. When combined with data from other laboratories, our marker set of 17,189 SNPs provides even coverage of the complete worm genome. To date, we have confirmed >1099 evenly spaced SNPs (one every 91 +/- 56 kb) across the six chromosomes and validated the utility of our SNP marker set and new fluorescence polarization-based genotyping methods for systematic and high-throughput identification of genes in C. elegans by cloning several proprietary genes. We illustrate our approach by recombination mapping and confirmation of the mutation in the cloned gene, dpy-18.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.