ArticleGenome research2002
Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo.bioRxiv : the preprint server for biology · 2026Article
- Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Inner ear organoids: Recent progress and potential applications.Fundamental research · 2025Review
- Study Models for Non-Syndromic Hearing Loss.Cells · 2025Review
- CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth.Journal of cellular biochemistry · 2018Article
- Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.PloS one · 2018Article
- Targeted Exome Sequencing IdentifiesJournal of the American Society of Nephrology : JASN · 2017Article
- Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system.BMC molecular biology · 2017Article
- Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity.Redox biology · 2016Article
- GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.Human molecular genetics · 2013Article
- The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack.Microarrays (Basel, Switzerland) · 2013Article
- Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear.PloS one · 2009Article
- Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors.Hearing research · 2009Article
- Synthesis of biotin-labeled RNA for gene expression measurements using oligonucleotide arrays.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Has hair cell loss MET its match?Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Ion channel gene expression in the inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
- Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have used Affymetrix high-density gene arrays to generate a temporal profile of gene expression during differentiation of UB/OC-1, a conditionally immortal cell line derived from the mouse cochlea. Gene expression was assessed daily for 14 days under differentiating conditions. The experiment was replicated in two separate populations of cells. Profiles for selected genes were correlated with those obtained by RT-PCR, TaqMan analysis, immunoblotting, and immunofluorescence. The results suggest that UB/OC-1 is derived from a population of nonsensory epithelial cells in the greater epithelial ridge that have the potential to differentiate into a hair-cell-like phenotype, without the intervention of Math1. Elements of the Notch signaling cascade were identified, including the receptor Notch3, with a transient up-regulation that suggests a role in hair cell differentiation. Several genes showed a profile similar to Notch3, including the transcriptional co-repressor Groucho1. UB/OC-1 also expressed Me1, a putative partner of Math1 that may confer competence to differentiate into hair cells. Cluster analysis revealed expression profiles for neural guidance genes associated with Gata3. The temporal dimension of this analysis provides a powerful tool to study genetic mechanisms that underlie the conversion of nonsensory epithelial cells into hair cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.