Evidence map›Paper›PMID 12097252›Full record

ReviewClinical microbiology reviews2002

Current status of nonculture methods for diagnosis of invasive fungal infections.

Siew Fah Yeo, Brian Wong

Open access · greenAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 281 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Siew Fah YeoInfectious Disease Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Brian Wong
VA Connecticut Healthcare System · USYale University · US

Funding

ESSENTIAL PROTEIN SECRETION GENES OF CANDIDA ALBICANSR01AI047442 · NIAID · YALE UNIVERSITY · PI WONG, BRIAN · 2000 to 2003
$1.0M
MANNITOL AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANSR01AI036684 · NIAID · YALE UNIVERSITY · PI WONG, BRIAN · 1994 to 2002
$673k
MANNITOL AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANSR21AI036684 · NIAID · YALE UNIVERSITY · PI WONG, BRIAN · 1998 to 1998
–
NIAID NIH HHS AI-36684NIAID NIH HHS AI-47442NIAID NIH HHS R01 AI047442
6 · The paper itself

Abstract

The incidence of invasive fungal infections has increased dramatically in recent decades, especially among immunocompromised patients. However, the diagnosis of these infections in a timely fashion is often very difficult. Conventional microbiologic and histopathologic approaches generally are neither sensitive nor specific, and they often do not detect invasive fungal infection until late in the course of disease. Since early diagnosis may guide appropriate treatment and prevent mortality, there has been considerable interest in developing nonculture approaches to diagnosing fungal infections. These approaches include detection of specific host immune responses to fungal antigens, detection of specific macromolecular antigens using immunologic reagents, amplification and detection of specific fungal nucleic acid sequences, and detection and quantitation of specific fungal metabolite products. This work reviews the current status and recent developments as well as problems in the design of nonculture diagnostic methods for invasive fungal infections.

Indexed as

Mitosporic FungiAntibodies, FungalAntigens, FungalDNA, FungalHumansMycological Typing TechniquesMycosesAntibodies, FungalAntigens, FungalDNA, Fungal

Identifiers

PMID12097252
PMCPMC118074
OpenAlexW2109760545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.