Trial reportThorax2002
Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance.
Trial report in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia. A Systematic Review and Meta-analysis.Annals of the American Thoracic Society · 2017Pooled it
- Diagnostic accuracy of nasal nitric oxide for establishing diagnosis of primary ciliary dyskinesia: a meta-analysis.BMC pulmonary medicine · 2015Pooled it
- Convergence of autism proteins at the cilium.bioRxiv : the preprint server for biology · 2025Article
- Primary Ciliary Dyskinesia: A Clinical Review.Cells · 2024Review
- Impaired Nitric Oxide Synthetase Activity in Primary Ciliary Dyskinesia-Data-Driven Hypothesis.Journal of clinical medicine · 2023Article
- Can Leukotriene Receptor Antagonist Therapy Improve the Control of Patients with Severe Asthma on Biological Therapy and Coexisting Bronchiectasis? A Pilot Study.Journal of clinical medicine · 2022Article
- An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia.ERJ open research · 2022Article
- Motile ciliopathies.Nature reviews. Disease primers · 2020Review
- The value of nasal nitric oxide measurement in the diagnosis of primary ciliary dyskinesia.Pediatric investigation · 2019Article
- Spirometric indices in primary ciliary dyskinesia: systematic review and meta-analysis.ERJ open research · 2019Review
- Nasal Nitric Oxide in Primary Immunodeficiency and Primary Ciliary Dyskinesia: Helping to Distinguish Between Clinically Similar Diseases.Journal of clinical immunology · 2019Article
- Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis.Multidisciplinary respiratory medicine · 2018Review
- Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia.American journal of respiratory and critical care medicine · 2017Article
- Whole-exome sequencing identification of novel DNAH5 mutations in a young patient with primary ciliary dyskinesia.Molecular medicine reports · 2016Article
- Effect of Cilia Beat Frequency on Muco-ciliary Clearance.Journal of biomedical physics & engineering · 2016Article
- Normal values of nasal NO and exhaled NO in young Chinese people aged 9 - 22 years.World journal of otorhinolaryngology - head and neck surgery · 2016Article
- Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis.Italian journal of pediatrics · 2016Article
- Oxidative Stress and Therapeutic Development in Lung Diseases.Journal of pulmonary & respiratory medicine · 2014Article
- Primary Ciliary Dyskinesia: An Update on New Diagnostic Modalities and Review of the Literature.Pediatric allergy, immunology, and pulmonology · 2014Review
- Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia.Annals of the American Thoracic Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe levels of exhaled and nasal nitric oxide (eNO and nNO) in groups of patients with inflammatory lung diseases are well documented but the diagnostic use of these measurements in an individual is unknown.
methodsThe levels of nNO and eNO were compared in 31 children with primary ciliary dyskinesia (PCD), 21 with non-CF bronchiectasis (Bx), 17 with cystic fibrosis (CF), 35 with asthma (A), and 53 healthy controls (C) using a chemiluminescence NO analyser. A diagnostic receiver-operator characteristic (ROC) curve for PCD using NO was constructed.
resultsThe median (range) levels of nNO in parts per billion (ppb) in PCD, Bx, CF, and C were 60.3 (3.3-920), 533.6 (80-2053), 491.3 (31-1140), and 716 (398-1437), respectively; nNO levels were significantly lower in PCD than in all other groups (p<0.05). The median (range) levels of eNO in ppb in PCD, Bx, CF, A, and C were 2.0 (0.2-5.2), 5.4 (1.0-22.1), 2.6 (0.8-12.9), 10.7 (1.6-46.7), and 4.85 (2.5-18.3), respectively. The difference in eNO levels in PCD reached significance (p<0.05) when compared with those in Bx, A and C but not when compared with CF. Using the ROC curve, nNO of 250 ppb showed a sensitivity of 97% and a specificity of 90% for the diagnosis of PCD.
conclusionseNO and nNO cannot be used diagnostically to distinguish between most respiratory diseases. However, nNO in particular is a quick and useful diagnostic marker which may be used to screen patients with a clinical suspicion of PCD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.