ArticleProceedings of the National Academy of Sciences of the United States of America2002
dELL is an essential RNA polymerase II elongation factor with a general role in development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- The Arabidopsis thaliana AtCARP9 is a novel ELL ortholog and associates with AtEAF proteins.Planta · 2026Article
- Sequence, structural and functional conservation among the human and fission yeast ELL and EAF transcription elongation factors.Molecular biology reports · 2022Article
- Writing and erasing MYC ubiquitination and SUMOylation.Genes & diseases · 2019Review
- The hunt for RNA polymerase II elongation factors: a historical perspective.Nature structural & molecular biology · 2019Review
- Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.Molecular immunology · 2017Article
- Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.The Journal of endocrinology · 2017Article
- ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.Nature communications · 2016Article
- Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.Experimental hematology · 2015Review
- P-TEFb, the super elongation complex and mediator regulate a subset of non-paused genes during early Drosophila embryo development.PLoS genetics · 2015Article
- Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach.Computational and mathematical methods in medicine · 2015Article
- TEF-7A, a transcript elongation factor gene, influences yield-related traits in bread wheat (Triticum aestivum L.).Journal of experimental botany · 2014Article
- System wide analyses have underestimated protein abundances and the importance of transcription in mammals.PeerJ · 2014Article
- The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.Molecular cell · 2013Article
- Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Transcriptional elongation checkpoint control in development and disease.Genes & development · 2013Review
- RNA polymerase II elongation control.Annual review of biochemistry · 2012Review
- Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis.Spermatogenesis · 2012Article
- The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.Annual review of biochemistry · 2012Review
- The little elongation complex regulates small nuclear RNA transcription.Molecular cell · 2011Article
- Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.The Journal of biological chemistry · 2011Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Several eukaryotic proteins increase RNA polymerase II (Pol II) transcription rates in vitro. The relative contributions of these factors to gene expression in vivo is unknown. The ELL family of proteins promote Pol II elongation in vitro, and the Drosophila ELL homolog (dELL) is associated with Pol II at sites of transcription in vivo. The purpose of this study was to test whether an ELL family protein is required for gene expression in vivo. We show that dELL is encoded by the Suppressor of Triplo-lethal locus [Su(Tpl)]. We have characterized seven distinct mutant alleles of Su(Tpl) and show that a dELL transgene rescues recessive lethality of Su(Tpl). Su(Tpl) mutations cause abnormal embryonic segmentation and dominantly modify expression of diverse genes during development. These data show that an ELL family elongation factor is essential, acts broadly in development, and is not functionally redundant to other elongation factors in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.