ArticleThe Journal of physiology2002
Potentiation of 'on' bipolar cell flash responses by dim background light and cGMP in dogfish retinal slices.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The Hidden Benefits of Noise: Low-Frequency tRNS and Dynamic Visual Noise Enhance Visual Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- Stochastic resonance improves vision in the severely impaired.Scientific reports · 2017Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Light-evoked S-nitrosylation in the retina.The Journal of comparative neurology · 2015Article
- PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform.Frontiers in molecular neuroscience · 2014Article
- Identifying cell class specific losses from serially generated electroretinogram components.BioMed research international · 2013Article
- Ionotropic glutamate receptors mediate OFF responses in light-adapted ON bipolar cells.Vision research · 2012Article
- Neuronal functional diversity and collective behaviors: a scientific case.Cognitive processing · 2009Review
- Neuronal functional diversity and collective behaviors.Journal of biological physics · 2008Article
- Regulation of ON bipolar cell activity.Progress in retinal and eye research · 2008Review
- Melatonin potentiates rod signals to ON type bipolar cells in fish retina.The Journal of physiology · 2008Article
- Efficiency of synaptic transmission of single-photon events from rod photoreceptor to rod bipolar dendrite.Biophysical journal · 2006Article
- Controlling the gain of rod-mediated signals in the Mammalian retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- cGMP-dependent kinase regulates response sensitivity of the mouse on bipolar cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high sensitivity of the vertebrate visual system results from amplification inherent in phototransduction in rods and from the amplification of rod signals on their synaptic transfer at the first synapse with 'on' bipolar cells. These cells possess a metabotropic glutamate receptor linked via a cGMP cascade to the control of cGMP-activated channels. In the study presented here, we show that very dim background light, isomerising only one rhodopsin in 1 out of 10 rods per second, potentiates 'on' bipolar cell responses to superimposed flashes. Responses to dim flashes, which were undetectable above the noise in the dark, were boosted above the increased noise level induced by the background. This potentiation could be reproduced by elevating cGMP, which increases with light, or by dialysing the cells with a non-hydrolysable cGMP analogue. Inhibition of tyrosine kinase activity also reproduced the effect and induced a speeding up of the rising phase of the flash response, similar to the action of dim background light. Conversely, inhibition of tyrosine phosphatase activity blocked the potentiation. These results suggest that cGMP promotes tyrosine-site dephosphorylation of 'on' bipolar cell cGMP-activated channels, resulting in a rise in the sensitivity to cGMP, as has recently been demonstrated for rod cGMP-activated channels. This constitutes a positive feedback mechanism such that as cGMP increases with light, the sensitivity of the channels to cGMP increases and boosts the signal above background noise. This mechanism would allow stochastic resonance to occur, facilitating single-photon detection when dark-adapted, and may therefore lead to improved discrimination.
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